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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-8-26
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pubmed:abstractText |
Cell survival is determined by a balance among signaling cascades, including those that recruit the Akt and JNK pathways. Here we describe a novel interaction between Akt1 and JNK interacting protein 1 (JIP1), a JNK pathway scaffold. Direct association between Akt1 and JIP1 was observed in primary neurons. Neuronal exposure to an excitotoxic stimulus decreased the Akt1-JIP1 interaction and concomitantly increased association between JIP1 and JNK. Akt1 interaction with JIP1 inhibited JIP1-mediated potentiation of JNK activity by decreasing JIP1 binding to specific JNK pathway kinases. Consistent with this view, neurons from Akt1-deficient mice exhibited higher susceptibility to kainate than wild-type littermates. Overexpression of Akt1 mutants that bind JIP1 reduced excitotoxic apoptosis. These results suggest that Akt1 binding to JIP1 acts as a regulatory gate preventing JNK activation, which is released under conditions of excitotoxic injury.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Arabidopsis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/MAPK8IP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mapk8ip protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Mapk8ip protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
697-709
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12194869-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12194869-Animals,
pubmed-meshheading:12194869-Apoptosis,
pubmed-meshheading:12194869-Arabidopsis Proteins,
pubmed-meshheading:12194869-Carrier Proteins,
pubmed-meshheading:12194869-Cell Survival,
pubmed-meshheading:12194869-Cells, Cultured,
pubmed-meshheading:12194869-Central Nervous System Diseases,
pubmed-meshheading:12194869-Fetus,
pubmed-meshheading:12194869-Gene Deletion,
pubmed-meshheading:12194869-Gene Expression,
pubmed-meshheading:12194869-Glutamic Acid,
pubmed-meshheading:12194869-Hippocampus,
pubmed-meshheading:12194869-Humans,
pubmed-meshheading:12194869-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:12194869-Kainic Acid,
pubmed-meshheading:12194869-Mice,
pubmed-meshheading:12194869-Mice, Knockout,
pubmed-meshheading:12194869-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12194869-Neurons,
pubmed-meshheading:12194869-Neurotoxins,
pubmed-meshheading:12194869-Plant Proteins,
pubmed-meshheading:12194869-Potassium Channels,
pubmed-meshheading:12194869-Protein Binding,
pubmed-meshheading:12194869-Rats,
pubmed-meshheading:12194869-Rats, Sprague-Dawley,
pubmed-meshheading:12194869-Receptors, Glutamate,
pubmed-meshheading:12194869-Signal Transduction
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pubmed:year |
2002
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pubmed:articleTitle |
Akt1 regulates a JNK scaffold during excitotoxic apoptosis.
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pubmed:affiliation |
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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