| pubmed-article:12193754 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12193754 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:12193754 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:12193754 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:12193754 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:12193754 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:12193754 | lifeskim:mentions | umls-concept:C0108779 | lld:lifeskim |
| pubmed-article:12193754 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:12193754 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12193754 | pubmed:dateCreated | 2002-8-23 | lld:pubmed |
| pubmed-article:12193754 | pubmed:abstractText | Infection with the HIV type 1 (HIV-1) can result both in depletion of CD4(+) T cells and in the generation of dysfunctional CD8(+) T cells. In HIV-1-infected children, repopulation of the peripheral T cell pool is mediated by the thymus, which is itself susceptible to HIV-1 infection. Previous work has shown that MHC class I (MHC I) molecules are strongly up-regulated as result of IFN-alpha secretion in the HIV-1-infected thymus. We demonstrate in this study that increased MHC I up-regulation on thymic epithelial cells and double-positive CD3(-/int)CD4(+)CD8(+) thymocytes correlates with the generation of mature single-positive CD4(-)CD8(+) thymocytes that have low expression of CD8. Treatment of HIV-1-infected thymus with highly active antiretroviral therapy normalizes MHC I expression and surface CD8 expression on such CD4(-)CD8(+) thymocytes. In pediatric patients with possible HIV-1 infection of the thymus, a low CD3 percentage in the peripheral circulation is also associated with a CD8(low) phenotype on circulating CD3(+)CD8(+) T cells. Furthermore, CD8(low) peripheral T cells from these HIV-1(+) pediatric patients are less responsive to stimulation by Ags from CMV. These data indicate that IFN-alpha-mediated MHC I up-regulation on thymic epithelial cells may lead to high avidity interactions with developing double-positive thymocytes and drive the selection of dysfunctional CD3(+)CD8(low) T cells. We suggest that this HIV-1-initiated selection process may contribute to the generation of dysfunctional CD8(+) T cells in HIV-1-infected patients. | lld:pubmed |
| pubmed-article:12193754 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193754 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193754 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193754 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193754 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12193754 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193754 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12193754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193754 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12193754 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12193754 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12193754 | pubmed:author | pubmed-author:NixonDouglas... | lld:pubmed |
| pubmed-article:12193754 | pubmed:author | pubmed-author:KeirMary EME | lld:pubmed |
| pubmed-article:12193754 | pubmed:author | pubmed-author:StoddartChery... | lld:pubmed |
| pubmed-article:12193754 | pubmed:author | pubmed-author:McCuneJoseph... | lld:pubmed |
| pubmed-article:12193754 | pubmed:author | pubmed-author:WizniaAndrewA | lld:pubmed |
| pubmed-article:12193754 | pubmed:author | pubmed-author:SandbergJohan... | lld:pubmed |
| pubmed-article:12193754 | pubmed:author | pubmed-author:RosenbergMich... | lld:pubmed |
| pubmed-article:12193754 | pubmed:author | pubmed-author:JordanKimberl... | lld:pubmed |
| pubmed-article:12193754 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12193754 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12193754 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:12193754 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12193754 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12193754 | pubmed:pagination | 2788-96 | lld:pubmed |
| pubmed-article:12193754 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12193754 | pubmed:meshHeading | pubmed-meshheading:12193754... | lld:pubmed |
| pubmed-article:12193754 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12193754 | pubmed:articleTitle | Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus. | lld:pubmed |
| pubmed-article:12193754 | pubmed:affiliation | Biomedical Sciences Graduate Program, University of California, San Francisco 94143, USA. | lld:pubmed |
| pubmed-article:12193754 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12193754 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12193754 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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