Source:http://linkedlifedata.com/resource/pubmed/id/12193754
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2002-8-23
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| pubmed:abstractText |
Infection with the HIV type 1 (HIV-1) can result both in depletion of CD4(+) T cells and in the generation of dysfunctional CD8(+) T cells. In HIV-1-infected children, repopulation of the peripheral T cell pool is mediated by the thymus, which is itself susceptible to HIV-1 infection. Previous work has shown that MHC class I (MHC I) molecules are strongly up-regulated as result of IFN-alpha secretion in the HIV-1-infected thymus. We demonstrate in this study that increased MHC I up-regulation on thymic epithelial cells and double-positive CD3(-/int)CD4(+)CD8(+) thymocytes correlates with the generation of mature single-positive CD4(-)CD8(+) thymocytes that have low expression of CD8. Treatment of HIV-1-infected thymus with highly active antiretroviral therapy normalizes MHC I expression and surface CD8 expression on such CD4(-)CD8(+) thymocytes. In pediatric patients with possible HIV-1 infection of the thymus, a low CD3 percentage in the peripheral circulation is also associated with a CD8(low) phenotype on circulating CD3(+)CD8(+) T cells. Furthermore, CD8(low) peripheral T cells from these HIV-1(+) pediatric patients are less responsive to stimulation by Ags from CMV. These data indicate that IFN-alpha-mediated MHC I up-regulation on thymic epithelial cells may lead to high avidity interactions with developing double-positive thymocytes and drive the selection of dysfunctional CD3(+)CD8(low) T cells. We suggest that this HIV-1-initiated selection process may contribute to the generation of dysfunctional CD8(+) T cells in HIV-1-infected patients.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
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| pubmed:volume |
169
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2788-96
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12193754-Antigens, CD3,
pubmed-meshheading:12193754-Antigens, CD8,
pubmed-meshheading:12193754-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12193754-Cell Line,
pubmed-meshheading:12193754-Child,
pubmed-meshheading:12193754-Child, Preschool,
pubmed-meshheading:12193754-Down-Regulation,
pubmed-meshheading:12193754-Epithelial Cells,
pubmed-meshheading:12193754-Female,
pubmed-meshheading:12193754-Fetus,
pubmed-meshheading:12193754-HIV Infections,
pubmed-meshheading:12193754-HIV-1,
pubmed-meshheading:12193754-Histocompatibility Antigens Class I,
pubmed-meshheading:12193754-Humans,
pubmed-meshheading:12193754-Interferon-alpha,
pubmed-meshheading:12193754-Male,
pubmed-meshheading:12193754-Organ Culture Techniques,
pubmed-meshheading:12193754-T-Lymphocyte Subsets,
pubmed-meshheading:12193754-Thymus Gland,
pubmed-meshheading:12193754-Up-Regulation
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus.
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| pubmed:affiliation |
Biomedical Sciences Graduate Program, University of California, San Francisco 94143, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|