| pubmed-article:12193540 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12193540 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:12193540 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:12193540 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12193540 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:12193540 | lifeskim:mentions | umls-concept:C0040661 | lld:lifeskim |
| pubmed-article:12193540 | lifeskim:mentions | umls-concept:C1705162 | lld:lifeskim |
| pubmed-article:12193540 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:12193540 | lifeskim:mentions | umls-concept:C0000431 | lld:lifeskim |
| pubmed-article:12193540 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12193540 | pubmed:dateCreated | 2002-8-23 | lld:pubmed |
| pubmed-article:12193540 | pubmed:abstractText | We are investigating the mechanisms by which aromatic hydrocarbons, such as 3-methylcholanthrene (MC), suppress hepatic cytochrome P450 2C11 (CYP2C11) gene expression. CYP2C11 is an enzyme expressed in the liver of male rats and is regulated by a pulsatile pattern of GH secretion. We have previously shown that MC attenuates the stimulatory effect of GH on CYP2C11 expression in hypophysectomized male rats. In follow-up studies we evaluated the effect of MC on GH-stimulated signal transducer and activator of transcription 5b (STAT5b) phosphorylation, nuclear translocation, and DNA-binding activity. GH-stimulated increases in hepatic nuclear STAT5b and phospho-STAT5b levels were not different between groups of hypophysectomized rats receiving MC or vehicle. This observation was corroborated at the DNA-binding level by EMSA. We also measured GH-induced STAT5b activation in the H4IIE rat hepatoma cell line. STAT5b DNA-binding activity detected in GH-treated cells was not affected by MC. Immunocytochemistry experiments revealed no effect of MC on GH-stimulated STAT5b nuclear translocation in H4IIE cells. These in vivo and in vitro data suggest that interference with GH-stimulated STAT5b activation does not constitute a mechanism by which MC attenuates the stimulatory effect of GH on CYP2C11 gene expression. | lld:pubmed |
| pubmed-article:12193540 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12193540 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193540 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12193540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12193540 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12193540 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12193540 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:12193540 | pubmed:author | pubmed-author:TimsitYoav... | lld:pubmed |
| pubmed-article:12193540 | pubmed:author | pubmed-author:RiddickDavid... | lld:pubmed |
| pubmed-article:12193540 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12193540 | pubmed:volume | 143 | lld:pubmed |
| pubmed-article:12193540 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12193540 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12193540 | pubmed:pagination | 3284-94 | lld:pubmed |
| pubmed-article:12193540 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:meshHeading | pubmed-meshheading:12193540... | lld:pubmed |
| pubmed-article:12193540 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12193540 | pubmed:articleTitle | Stimulation of hepatic signal transducer and activator of transcription 5b by GH is not altered by 3-methylcholanthrene. | lld:pubmed |
| pubmed-article:12193540 | pubmed:affiliation | Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S 1A8. | lld:pubmed |
| pubmed-article:12193540 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12193540 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:25126 | entrezgene:pubmed | pubmed-article:12193540 | lld:entrezgene |
