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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2002-8-22
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pubmed:abstractText |
When cells were incubated in the presence of both interferon-gamma (IFN-gamma) and all-trans retinoic acid (ATRA), the concentration of IFN-gamma required to induce apoptosis of B-cell lymphoma cells was much lower than that required for myeloid or erythroid cell lines. The concentration of IFN-gamma that effectively inhibited the proliferation of BALM-3 cells was 1/40 of that required for BALM-1 cells. STAT-1 phosphorylation, IRF-1 mRNA and protein expression and RAR-beta expression were enhanced to a greater degree in BALM-3 cells treated with IFN-gamma and ATRA than in BALM-1 cells treated with IFN-gamma and ATRA, suggesting that these IFN-gamma related genes were involved in the induction of apoptosis of BALM-3 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IRF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/retinoic acid receptor beta
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0145-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
745-55
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12191570-Apoptosis,
pubmed-meshheading:12191570-DNA-Binding Proteins,
pubmed-meshheading:12191570-Dose-Response Relationship, Drug,
pubmed-meshheading:12191570-Drug Synergism,
pubmed-meshheading:12191570-Humans,
pubmed-meshheading:12191570-Interferon Regulatory Factor-1,
pubmed-meshheading:12191570-Interferon-gamma,
pubmed-meshheading:12191570-Lymphoma, B-Cell,
pubmed-meshheading:12191570-Phosphoproteins,
pubmed-meshheading:12191570-Receptors, Retinoic Acid,
pubmed-meshheading:12191570-STAT1 Transcription Factor,
pubmed-meshheading:12191570-Trans-Activators,
pubmed-meshheading:12191570-Tretinoin,
pubmed-meshheading:12191570-Tumor Cells, Cultured,
pubmed-meshheading:12191570-Up-Regulation
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pubmed:year |
2002
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pubmed:articleTitle |
Human B-cell lymphoma cell lines are highly sensitive to apoptosis induced by all-trans retinoic acid and interferon-gamma.
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pubmed:affiliation |
Department of Hematology and Internal Medicine IV, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara-shi, Kanagawa 228-8555, Japan. nniitsu@med.kitasato-u.ac.jp
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pubmed:publicationType |
Journal Article
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