Linked Life Data

12191502

Source:http://linkedlifedata.com/resource/pubmed/id/12191502

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2002-8-22
pubmed:abstractText
The diminished expression of D1 and D2 dopamine receptors is a well-documented hallmark of Huntington's disease (HD), but relatively little is known about how these changes in receptor populations affect the dopaminergic responses of striatal neurons. Using transgenic mice expressing an N-terminal portion of mutant huntingtin (R6/2 mice), we have examined immediate early gene (IEG) expression as an index of dopaminergic signal transduction. c-fos, jun B, zif268, and N10 mRNA levels and expression patterns were analyzed using quantitative in situ hybridization histochemistry following intraperitoneal administration of selective D1 and D2 family pharmacological agents (SKF-82958 and eticlopride). Basal IEG levels were generally lower in the dorsal subregion of R6/2 striata relative to wild-type control striata at 10-11 weeks of age, a finding in accord with previously reported decreases in D1 and adenosine A2A receptors. D2-antagonist-stimulated IEG expression was significantly reduced in the striata of transgenic animals. In contrast, D1-agonist-induced striatal R6/2 IEG mRNA levels were either equivalent or significantly enhanced relative to control levels, an unexpected result given the reduced level of D1 receptors in R6/2 animals. Understanding the functional bases for these effects may further elucidate the complex pathophysiology of Huntington's disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0169-328X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
118-28
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12191502-Animals, pubmed-meshheading:12191502-Disease Models, Animal, pubmed-meshheading:12191502-Dopamine Agonists, pubmed-meshheading:12191502-Dopamine Antagonists, pubmed-meshheading:12191502-Female, pubmed-meshheading:12191502-Gene Expression Regulation, pubmed-meshheading:12191502-Genes, Immediate-Early, pubmed-meshheading:12191502-Huntington Disease, pubmed-meshheading:12191502-Male, pubmed-meshheading:12191502-Mice, pubmed-meshheading:12191502-Mice, Transgenic, pubmed-meshheading:12191502-Neostriatum, pubmed-meshheading:12191502-Nerve Tissue Proteins, pubmed-meshheading:12191502-Neurons, pubmed-meshheading:12191502-Nuclear Proteins, pubmed-meshheading:12191502-RNA, Messenger, pubmed-meshheading:12191502-Receptors, Dopamine D1, pubmed-meshheading:12191502-Receptors, Dopamine D2, pubmed-meshheading:12191502-Transcriptional Activation
pubmed:year
2002
pubmed:articleTitle
Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington's disease.
pubmed:affiliation
Department of Neurology and Center for Aging, Genetics, and Neurodegeneration, Neurology/B114-2001, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129-4404, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't