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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-8-21
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pubmed:abstractText |
The human milk fat globule membrane protein BA46 (lactadherin) is highly overexpressed in human breast tumors, making it a potential target for tumor immunotherapy. We have identified BA46-derived peptides that contain the motif recognized by the MHC class I molecule HLA-A2.1 and that are processed and presented by human breast carcinoma cells. In mice lacking normal class I molecules but expressing an HLA-A2.1/D(b)-beta2 microglobulin single chain (HHD mice), three peptides elicited specific CTL activity. Two of these peptides also stimulated cytotoxic activity in peripheral blood lymphocytes from HLA-A2.1-positive breast carcinoma patients. Adoptive transfer of HHD-derived bulk CTLs to nude mice bearing human breast carcinoma transplants reduced tumor growth. These peptides therefore represent naturally processed BA46-derived CTL epitopes that can be used in peptide-based antitumor vaccines.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-10361129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-10411933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-10626733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-10652432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-10700237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-11169964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-11300482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-11358828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-11745343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-12000961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-1909932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-2122462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-2469442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-3802085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-6957872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-7493358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-7527444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-7533182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-7682582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-7895173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-8476560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-8566090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-8620523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-8639264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-8780713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-9079808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-9182675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-9535276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12189239-9643686
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A2 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/MFGE8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mfge8 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Milk Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9738
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pubmed:author |
pubmed-author:Bar-HaimErezE,
pubmed-author:Bobilev-PrielIreneI,
pubmed-author:BobilevDimitryD,
pubmed-author:BrennerBaruchB,
pubmed-author:CarmonLiorL,
pubmed-author:EisenbachLeaL,
pubmed-author:FridkinMatiM,
pubmed-author:KleinTirzaT,
pubmed-author:LemonnierFrancoisF,
pubmed-author:PazAdrianA,
pubmed-author:TiroshBoazB,
pubmed-author:TzehovalEstherE
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pubmed:issnType |
Print
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
453-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12189239-Adoptive Transfer,
pubmed-meshheading:12189239-Animals,
pubmed-meshheading:12189239-Antigens, Surface,
pubmed-meshheading:12189239-Breast Neoplasms,
pubmed-meshheading:12189239-Carcinoma,
pubmed-meshheading:12189239-Cell Extracts,
pubmed-meshheading:12189239-Epitopes,
pubmed-meshheading:12189239-Female,
pubmed-meshheading:12189239-HLA-A2 Antigen,
pubmed-meshheading:12189239-Humans,
pubmed-meshheading:12189239-Mice,
pubmed-meshheading:12189239-Mice, Knockout,
pubmed-meshheading:12189239-Mice, Nude,
pubmed-meshheading:12189239-Mice, Transgenic,
pubmed-meshheading:12189239-Milk Proteins,
pubmed-meshheading:12189239-Neoplasm Proteins,
pubmed-meshheading:12189239-Peptides,
pubmed-meshheading:12189239-RNA, Neoplasm,
pubmed-meshheading:12189239-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:12189239-Tumor Cells, Cultured,
pubmed-meshheading:12189239-beta 2-Microglobulin
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pubmed:year |
2002
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pubmed:articleTitle |
Characterization of novel breast carcinoma-associated BA46-derived peptides in HLA-A2.1/D(b)-beta2m transgenic mice.
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pubmed:affiliation |
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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pubmed:publicationType |
Journal Article
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