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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-8-20
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pubmed:abstractText |
Background genetic factors may influence the variability in the rate of progression of kidney disease in type 1 diabetes. In diabetes, progressive mesangial matrix expansion and glomerular sclerosis are, to a large extent, mediated by TGF-beta1. Decorin, a proteoglycan which is a component of the extracellular matrix, regulates TGF-beta1 activity and expression. We have examined the relationship between the 179/183/185 polymorphism of the Decorin gene and the progression of diabetic nephropathy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0028-2766
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pubmed:author |
pubmed-author:BacciSS,
pubmed-author:Cavallo PerinPP,
pubmed-author:CisterninoCC,
pubmed-author:De CosmoSS,
pubmed-author:PirasG PGP,
pubmed-author:TassiVV,
pubmed-author:ThomasSS,
pubmed-author:TrevisanRR,
pubmed-author:TrischittaVV,
pubmed-author:VibertiG CGC,
pubmed-author:ZucaroLL
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pubmed:copyrightInfo |
Copyright 2002 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
72-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12187087-Adult,
pubmed-meshheading:12187087-Alleles,
pubmed-meshheading:12187087-Cells, Cultured,
pubmed-meshheading:12187087-Creatinine,
pubmed-meshheading:12187087-Decorin,
pubmed-meshheading:12187087-Diabetes Mellitus, Type 1,
pubmed-meshheading:12187087-Diabetic Nephropathies,
pubmed-meshheading:12187087-Disease Progression,
pubmed-meshheading:12187087-Extracellular Matrix Proteins,
pubmed-meshheading:12187087-Female,
pubmed-meshheading:12187087-Fibroblasts,
pubmed-meshheading:12187087-Genotype,
pubmed-meshheading:12187087-Humans,
pubmed-meshheading:12187087-Male,
pubmed-meshheading:12187087-Polymorphism, Genetic,
pubmed-meshheading:12187087-Proteinuria,
pubmed-meshheading:12187087-Proteoglycans,
pubmed-meshheading:12187087-Skin
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pubmed:year |
2002
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pubmed:articleTitle |
The Decorin gene 179 allelic variant is associated with a slower progression of renal disease in patients with type 1 diabetes.
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pubmed:affiliation |
Clinical and Research Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza San Giovanni Rotondo (FG), Italy. sdecosm@tin.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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