Source:http://linkedlifedata.com/resource/pubmed/id/12187055
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2002-8-20
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| pubmed:abstractText |
The presence of metastatic disease in patients newly diagnosed with medulloblastoma remains one of the most important prognostic factors that determines event-free survival. In the present study, anatomic distribution and the signal characteristics and enhancement patterns of subtle anterior third ventricular recess metastases were compared with those of the original tumor; medical records were reviewed for clinical presentation, surgical stage, treatment and long-term outcomes. All foci were clinically occult; 5 out of 6 had negative cerebrospinal fluid cytology, and in 4 out of 6, the only evidence of metastatic disease was documented suprasellar disease that resolved or significantly improved following irradiation and chemotherapy. Histologically, 3 of the 6 patients had tumors with large cell/anaplastic features, a significant increase compared to the expected incidence of 4-8.8%. Patients with tumors that show large cell/anaplastic features may be at higher risk for early metastatic involvement of this unusual site.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1016-2291
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2002 S. Karger AG, Basel
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| pubmed:issnType |
Print
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| pubmed:volume |
37
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
111-7
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12187055-Brain Neoplasms,
pubmed-meshheading:12187055-Brain Stem,
pubmed-meshheading:12187055-Cerebellar Neoplasms,
pubmed-meshheading:12187055-Cervical Vertebrae,
pubmed-meshheading:12187055-Child,
pubmed-meshheading:12187055-Child, Preschool,
pubmed-meshheading:12187055-Female,
pubmed-meshheading:12187055-Humans,
pubmed-meshheading:12187055-Lumbar Vertebrae,
pubmed-meshheading:12187055-Magnetic Resonance Imaging,
pubmed-meshheading:12187055-Male,
pubmed-meshheading:12187055-Medulloblastoma,
pubmed-meshheading:12187055-Meningeal Neoplasms,
pubmed-meshheading:12187055-Neoplasm Metastasis,
pubmed-meshheading:12187055-Neoplasm Staging,
pubmed-meshheading:12187055-Spinal Neoplasms,
pubmed-meshheading:12187055-Third Ventricle,
pubmed-meshheading:12187055-Thoracic Vertebrae
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Medulloblastoma metastatic to the suprasellar region at diagnosis: a report of six cases with clinicopathologic correlation.
|
| pubmed:affiliation |
St. Jude Children's Research Hospital, Semmes-Murphy Clinic, Memphis, TN 38105, USA. kathleen.helton@stjude.org
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|