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rdf:type |
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lifeskim:mentions |
umls-concept:C0021745,
umls-concept:C0026809,
umls-concept:C0032305,
umls-concept:C0035820,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205217,
umls-concept:C0683598,
umls-concept:C1167395,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
9
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pubmed:dateCreated |
2002-8-16
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pubmed:abstractText |
Although a clear relationship between alphabeta T-cell receptor-positive (alphabeta-TCR(+)) CD4(+) T cells and susceptibility to Pneumocystis carinii infection exists, the role of other T-cell subsets is less clearly defined. Previous studies have shown that gammadelta-TCR(+) T cells infiltrate into the lung during P. carinii pneumonia. Therefore, the present study examined the role of gammadelta-TCR(+) T cells in host defense against P. carinii pneumonia. C57BL/6 (control) and B6.129P2-Tcrd(tm1Mom) (gammadelta-TCR(+) T-cell-deficient) mice were inoculated intratracheally with P. carinii. At specific time points, mice were sacrificed and analyzed for P. carinii burden, T-cell subsets, and cytokine levels in lung tissue. Analysis of P. carinii burden showed a more rapid and complete resolution of infection in gammadelta-TCR(+) T-cell-deficient mice than in C57BL/6 controls. This augmented resolution was associated with elevated gamma interferon (IFN-gamma) levels in bronchoalveolar lavage fluid predominantly produced by CD8(+) T cells, as well as an increased recruitment of CD8(+) T cells in general. In separate experiments, neutralization of IFN-gamma or depletion of CD8(+) T cells early during infection abolished the augmented resolution previously observed in gammadelta-TCR(+) T-cell-deficient mice. These results show that the presence of gammadelta-TCR(+) T cells modulates host susceptibility to P. carinii pneumonia through interactions with pulmonary CD8(+) T cells and tissue production of IFN-gamma.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-10072538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-10227967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-10458760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-10545529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-10751350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-10946293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-11309709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-11485658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-11531320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-11705890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-11714738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-1548057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-1679991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-1682252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-2126500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-2139668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-7642318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-7692576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-7718193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-8031525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-8105480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-8751950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-8757854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-8900290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-8955202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-9001290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-9001292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-9009285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-9013962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-9032117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-9126975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183572-9151783
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5208-15
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12183572-Animals,
pubmed-meshheading:12183572-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12183572-Cytokines,
pubmed-meshheading:12183572-Interferon-gamma,
pubmed-meshheading:12183572-Lymphocyte Depletion,
pubmed-meshheading:12183572-Male,
pubmed-meshheading:12183572-Mice,
pubmed-meshheading:12183572-Mice, Inbred C57BL,
pubmed-meshheading:12183572-Mice, Knockout,
pubmed-meshheading:12183572-Mice, Mutant Strains,
pubmed-meshheading:12183572-Neutralization Tests,
pubmed-meshheading:12183572-Pneumonia, Pneumocystis,
pubmed-meshheading:12183572-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:12183572-T-Lymphocyte Subsets
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pubmed:year |
2002
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pubmed:articleTitle |
Increased host resistance against Pneumocystis carinii pneumonia in gammadelta T-cell-deficient mice: protective role of gamma interferon and CD8(+) T cells.
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pubmed:affiliation |
Section of Pulmonary and Critical Care and Gene Therapy Program, School of Medicine, Louisiana State University Health Sciences Center, New Orleans 70112, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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