| pubmed-article:12183548 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12183548 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12183548 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:12183548 | lifeskim:mentions | umls-concept:C0032269 | lld:lifeskim |
| pubmed-article:12183548 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12183548 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12183548 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:12183548 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:12183548 | lifeskim:mentions | umls-concept:C0599896 | lld:lifeskim |
| pubmed-article:12183548 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12183548 | pubmed:dateCreated | 2002-8-16 | lld:pubmed |
| pubmed-article:12183548 | pubmed:abstractText | Streptococcus pneumoniae infections are associated with considerable morbidity and mortality throughout the world. The immunopathology is characterized by an intense inflammatory reaction, including a strong acute-phase response and increased numbers of neutrophils in the circulation. However, little is known regarding the T-cell response during in vivo infections in humans. The purpose of this study was to test the hypothesis that activated T cells producing type 1 cytokines were engaged in the host response to pneumococcal infections. The phenotype and function of T cells were studied in 22 patients at admission to a department of infectious diseases and after antibiotic treatment for 1 week compared with an age-matched, healthy control group. Pneumococcal infections induced lymphopenia in the circulation due to the disappearance of activated T lymphocytes with a type 1 cytokine profile. In contrast, the numbers of naive T cells and interleukin-4-producing T cells did not change. Activated type 1 cytokine-producing cells reappeared in the circulation in relation to the treatment and clinical improvement. The underlying mechanisms during infection may include sequestration in the peripheral tissues and/or apoptosis. In fact, increased activation-induced apoptosis in the remaining peripheral lymphocytes and elevated levels of soluble Fas ligand were detected at admission to the hospital. In conclusion, these data suggest that activated T lymphocytes with a type 1 cytokine profile are highly engaged in the in vivo immune response to S. pneumoniae. | lld:pubmed |
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| pubmed-article:12183548 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12183548 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12183548 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12183548 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12183548 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12183548 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:12183548 | pubmed:author | pubmed-author:SkinhøjPeterP | lld:pubmed |
| pubmed-article:12183548 | pubmed:author | pubmed-author:BruunsgaardHe... | lld:pubmed |
| pubmed-article:12183548 | pubmed:author | pubmed-author:KempKåreK | lld:pubmed |
| pubmed-article:12183548 | pubmed:author | pubmed-author:Klarlund... | lld:pubmed |
| pubmed-article:12183548 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12183548 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:12183548 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12183548 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12183548 | pubmed:pagination | 5019-25 | lld:pubmed |
| pubmed-article:12183548 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12183548 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12183548 | pubmed:articleTitle | Pneumococcal infections in humans are associated with increased apoptosis and trafficking of type 1 cytokine-producing T cells. | lld:pubmed |
| pubmed-article:12183548 | pubmed:affiliation | Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:12183548 | pubmed:publicationType | Journal Article | lld:pubmed |
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