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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-8-16
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pubmed:abstractText |
Streptococcus pneumoniae infections are associated with considerable morbidity and mortality throughout the world. The immunopathology is characterized by an intense inflammatory reaction, including a strong acute-phase response and increased numbers of neutrophils in the circulation. However, little is known regarding the T-cell response during in vivo infections in humans. The purpose of this study was to test the hypothesis that activated T cells producing type 1 cytokines were engaged in the host response to pneumococcal infections. The phenotype and function of T cells were studied in 22 patients at admission to a department of infectious diseases and after antibiotic treatment for 1 week compared with an age-matched, healthy control group. Pneumococcal infections induced lymphopenia in the circulation due to the disappearance of activated T lymphocytes with a type 1 cytokine profile. In contrast, the numbers of naive T cells and interleukin-4-producing T cells did not change. Activated type 1 cytokine-producing cells reappeared in the circulation in relation to the treatment and clinical improvement. The underlying mechanisms during infection may include sequestration in the peripheral tissues and/or apoptosis. In fact, increased activation-induced apoptosis in the remaining peripheral lymphocytes and elevated levels of soluble Fas ligand were detected at admission to the hospital. In conclusion, these data suggest that activated T lymphocytes with a type 1 cytokine profile are highly engaged in the in vivo immune response to S. pneumoniae.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-10330421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-10353886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-10603404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-10858402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-10881678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-11038265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-11055658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-11377289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-11500454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-11506744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-11678901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-1458676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-7510905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-7528780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-7530337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-8972663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-8975920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-9199475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-9317012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-9461195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-9498956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-9519380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-9789052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183548-9826398
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5019-25
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12183548-Adult,
pubmed-meshheading:12183548-Aged,
pubmed-meshheading:12183548-Aged, 80 and over,
pubmed-meshheading:12183548-Apoptosis,
pubmed-meshheading:12183548-Cytokines,
pubmed-meshheading:12183548-Fas Ligand Protein,
pubmed-meshheading:12183548-Female,
pubmed-meshheading:12183548-Humans,
pubmed-meshheading:12183548-Immunologic Memory,
pubmed-meshheading:12183548-Interferon-gamma,
pubmed-meshheading:12183548-Interleukin-2,
pubmed-meshheading:12183548-Lymphocyte Activation,
pubmed-meshheading:12183548-Lymphocyte Count,
pubmed-meshheading:12183548-Male,
pubmed-meshheading:12183548-Membrane Glycoproteins,
pubmed-meshheading:12183548-Middle Aged,
pubmed-meshheading:12183548-Pneumococcal Infections,
pubmed-meshheading:12183548-Streptococcus pneumoniae,
pubmed-meshheading:12183548-T-Lymphocyte Subsets,
pubmed-meshheading:12183548-Tumor Necrosis Factor-alpha
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pubmed:year |
2002
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pubmed:articleTitle |
Pneumococcal infections in humans are associated with increased apoptosis and trafficking of type 1 cytokine-producing T cells.
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pubmed:affiliation |
Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
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pubmed:publicationType |
Journal Article
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