|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
18
|
|
pubmed:dateCreated |
2002-8-16
|
|
pubmed:abstractText |
A series of novel phenolic compounds has been discovered as potent inhibitors of TNF-alpha-inducible expression of vascular cell adhesion molecule-1 (VCAM-1) with concurrent antioxidant and lipid-modulating properties. Optimization of these multifunctional agents led to the identification of 3a (AGI-1067) as a clinical candidate with demonstrated efficacies in animal models of atherosclerosis and hyperlipidemia.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:HillRussell RRR,
pubmed-author:HoltLisa ALA,
pubmed-author:HoongLee KLK,
pubmed-author:KunschCharlesC,
pubmed-author:MengCharles QCQ,
pubmed-author:OlliffLynda KLK,
pubmed-author:ParthasarathySampathS,
pubmed-author:RachitaCarolyn LCL,
pubmed-author:SaxenaUdayU,
pubmed-author:SikorskiJames AJA,
pubmed-author:SimpsonJacob EJE,
pubmed-author:SomersPatricia KPK,
pubmed-author:SundellCynthia LCL,
pubmed-author:WassermanMartin AMA,
pubmed-author:ZhengX SharonXS
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
16
|
|
pubmed:volume |
12
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2545-8
|
|
pubmed:dateRevised |
2004-11-17
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis.
|
|
pubmed:affiliation |
AtheroGenics, Inc., 8995 Westside Parkway, GA 30004, Alpharetta, USA. cmeng@atherogenics.com
|
|
pubmed:publicationType |
Journal Article
|
