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| pubmed-article:12181742 | lifeskim:mentions | umls-concept:C1335268 | lld:lifeskim |
| pubmed-article:12181742 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:12181742 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:12181742 | lifeskim:mentions | umls-concept:C0004359 | lld:lifeskim |
| pubmed-article:12181742 | lifeskim:mentions | umls-concept:C0010656 | lld:lifeskim |
| pubmed-article:12181742 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:12181742 | lifeskim:mentions | umls-concept:C0004368 | lld:lifeskim |
| pubmed-article:12181742 | lifeskim:mentions | umls-concept:C1866199 | lld:lifeskim |
| pubmed-article:12181742 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:12181742 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12181742 | pubmed:dateCreated | 2002-8-15 | lld:pubmed |
| pubmed-article:12181742 | pubmed:abstractText | Lens epithelium-derived growth factor p75 (LEDGF/p75) is a nuclear autoantigen in atopic disorders implicated in cellular protection against stress-induced apoptosis. We observed that LEDGF/p75 was cleaved during apoptosis into fragments of 65 and 58 kD generated by caspases-3 and -7 cleaving at three sites: DEVPD30/G, DAQD486/G and WEID85/N. Sequence analysis revealed that the DEVPD30/G and WEID85/N sites lie within the highly conserved HATH (homologous to amino terminus of hepatoma-derived growth factor) region, also known as PWWP domain. Alignment of proteins containing this domain failed to reveal conservation of the DEVPD30/G and WEID85/N sites, suggesting that the HATH/PWWP domain of LEDGF/p75 may be specifically targeted by caspases. Overexpression of LEDGF/p75 protected HepG2 cells from serum starvation-induced cell death, whereas expression of the 65 kD fragment failed to protect. The apoptotic cleavage of LEDGF/p75 may contribute to the pathogenesis of atopic disorders by abrogating its pro-survival function and enhancing its immunogenicity. | lld:pubmed |
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| pubmed-article:12181742 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12181742 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12181742 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12181742 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12181742 | pubmed:issn | 1350-9047 | lld:pubmed |
| pubmed-article:12181742 | pubmed:author | pubmed-author:MolinariEE | lld:pubmed |
| pubmed-article:12181742 | pubmed:author | pubmed-author:DanieleFF | lld:pubmed |
| pubmed-article:12181742 | pubmed:author | pubmed-author:JogN VNV | lld:pubmed |
| pubmed-article:12181742 | pubmed:author | pubmed-author:LillyM BMB | lld:pubmed |
| pubmed-article:12181742 | pubmed:author | pubmed-author:CasianoC ACA | lld:pubmed |
| pubmed-article:12181742 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12181742 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:12181742 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12181742 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12181742 | pubmed:pagination | 915-25 | lld:pubmed |
| pubmed-article:12181742 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12181742 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12181742 | pubmed:articleTitle | Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders. | lld:pubmed |
| pubmed-article:12181742 | pubmed:affiliation | Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA. | lld:pubmed |
| pubmed-article:12181742 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12181742 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12181742 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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