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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-8-15
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pubmed:abstractText |
Relapses in non-Hodgkin's lymphomas (NHL) could be due to the reappearance of the initial neoplasm or new primary tumours. Discrimination between the two events would allow a more targeted therapeutic approach. VDJ rearrangement was used as marker of clonality in metachronous biopsy specimens from 10 patients with relapsed B-NHL. Complimentary determining region 3 was amplified and sequenced. D-JH was identical in eight matched primary/secondary tumours, confirming the diagnosis of recurrence. In contrast, primary and secondary tumours in two patients were of different clonal origin. Our data indicate that VDJ analysis is a fundamental tool for identification of relapses in NHL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0007-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
809-12
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12181049-Adult,
pubmed-meshheading:12181049-Aged,
pubmed-meshheading:12181049-Aged, 80 and over,
pubmed-meshheading:12181049-Base Sequence,
pubmed-meshheading:12181049-Complementarity Determining Regions,
pubmed-meshheading:12181049-DNA, Neoplasm,
pubmed-meshheading:12181049-Diagnosis, Differential,
pubmed-meshheading:12181049-Female,
pubmed-meshheading:12181049-Follow-Up Studies,
pubmed-meshheading:12181049-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:12181049-Humans,
pubmed-meshheading:12181049-Immunoglobulin Joining Region,
pubmed-meshheading:12181049-Immunoglobulin Variable Region,
pubmed-meshheading:12181049-Lymphoma, B-Cell,
pubmed-meshheading:12181049-Male,
pubmed-meshheading:12181049-Middle Aged,
pubmed-meshheading:12181049-Molecular Sequence Data,
pubmed-meshheading:12181049-Neoplasms, Second Primary,
pubmed-meshheading:12181049-Neoplastic Stem Cells,
pubmed-meshheading:12181049-Recurrence
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pubmed:year |
2002
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pubmed:articleTitle |
Differentiation between non-Hodgkin's lymphoma recurrence and second primary lymphoma by VDJ rearrangement analysis.
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pubmed:affiliation |
Division of Experimental Oncology 1, Centro di Riferimento Oncologico Aviano, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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