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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2002-8-15
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pubmed:abstractText |
Anti-Fas monoclonal antibodies (Mab) are considered to be a potential therapeutic agent for rheumatoid arthritis (RA). However, Fas mediated liver and chondrocyte damage is a serious problem in its clinical application. m-HFE7A, a novel anti-Fas Mab, selectively induces apoptosis in inflammatory cells. We succeeded in humanizing m-HFE7A to obtain h-HFE7A. We investigated the therapeutic effects of h-HFE7A Mab in RA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Antirheumatic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Fasl protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/anti-Fas monoclonal antibody
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0315-162X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1609-14
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12180717-Animals,
pubmed-meshheading:12180717-Antibodies, Monoclonal,
pubmed-meshheading:12180717-Antigens, CD95,
pubmed-meshheading:12180717-Antirheumatic Agents,
pubmed-meshheading:12180717-Apoptosis,
pubmed-meshheading:12180717-Arthritis, Rheumatoid,
pubmed-meshheading:12180717-Cells, Cultured,
pubmed-meshheading:12180717-Chimera,
pubmed-meshheading:12180717-Disease Models, Animal,
pubmed-meshheading:12180717-Fas Ligand Protein,
pubmed-meshheading:12180717-Humans,
pubmed-meshheading:12180717-Lymphocyte Activation,
pubmed-meshheading:12180717-Lymphocytes,
pubmed-meshheading:12180717-Membrane Glycoproteins,
pubmed-meshheading:12180717-Mice,
pubmed-meshheading:12180717-Mice, SCID,
pubmed-meshheading:12180717-Severe Combined Immunodeficiency,
pubmed-meshheading:12180717-Synovial Membrane,
pubmed-meshheading:12180717-Synovitis,
pubmed-meshheading:12180717-Transfection
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pubmed:year |
2002
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pubmed:articleTitle |
Antirheumatic effects of humanized anti-Fas monoclonal antibody in human rheumatoid arthritis/SCID mouse chimera.
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pubmed:affiliation |
Department of Orthopaedic Surgery, Toyama Medical and Pharmaceutical University, Japan. matsuno@ms.toyama-mpu.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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