Linked Life Data

12177357

Source:http://linkedlifedata.com/resource/pubmed/id/12177357

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 8
pubmed:dateCreated
2002-8-14
pubmed:abstractText
cAMP signalling has been shown to be essential for normal growth, morphology and virulence in fungal pathogens of both plants and animals. The effects of exogenous cAMP on the growth of the opportunistic pathogen Aspergillus fumigatus were compared to those of Aspergillus niger, which has previously been demonstrated to respond to extracellular cAMP. Both cAMP and phosphodiesterase inhibitors markedly reduced the radial growth rate of A. niger after 48 h on minimal medium with glucose as the carbon source, whereas the growth of A. fumigatus was not affected by cAMP. However, when glycerol, which does not initiate carbon catabolite repression, was used as a carbon source, cAMP inhibited the radial growth rate of only A. fumigatus (P<0.05). The addition of cAMP to glycerol-minimal medium resulted in a fourfold increase in protein kinase A activity in A. fumigatus cell extracts when compared with pre-treatment samples. The protein kinase A activity in A. fumigatus cell extracts from cultures grown in glucose did not change significantly with the addition of cAMP. These studies demonstrate that although the growth rates of both A. fumigatus and A. niger are sensitive to the addition of exogenous cAMP, the response of each organism is distinct and dependent on the carbon source used.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1350-0872
pubmed:author
pubmed:issnType
Print
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2627-33
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
cAMP alteration of growth rate of Aspergillus fumigatus and Aspergillus niger is carbon-source dependent.
pubmed:affiliation
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267-0529, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.