Linked Life Data

12176709

Source:http://linkedlifedata.com/resource/pubmed/id/12176709

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-8-14
pubmed:abstractText
The influences of aerosol size distribution and breath tidal volume on respirable dose estimates were examined for mouth breathing using the ACGIH/ISO/CEN criterion for respirable-equivalent aerosols. Actual tissue doses predicted from a set of pulmonary empirical deposition equations, the Heyder-Rudolf equations, were compared with deposition assumed to occur under the penetration-based respirable dust sampling criterion. Deposition estimate errors ranged from approximately 1/10- to 10-fold, with aerosol mass median aerodynamic equivalent diameter and geometric standard deviation as well as tidal volume each showing a substantial influence under appropriate conditions. These findings demonstrate that reliance on respirable aerosol sampling data obtained with devices performing on a penetration-based sampling criterion may lead to erroneous dose-response relationships in exposure standard development as well as exposure misclassification errors during epidemiological studies. A more reliable dose estimate would be obtained using devices with collection efficiency performance closely matching the alveolar deposition prediction curves of Heyder and Rudolf. We believe that if it is not currently required, the development of a deposition-based aerosol sampling methodology will soon be required for the determination and quantification of inhaled aerosol-induced adverse health effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0003-4878
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
401-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
The variability of delivered dose of aerosols with the same respirable concentration but different size distributions.
pubmed:affiliation
Aerosols Research Laboratory, University of Oklahoma Health Sciences Centre, PO Box 26901, Oklahoma City 73190, USA. nurtan-esmen@ouhsc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.