Linked Life Data

12176031

Source:http://linkedlifedata.com/resource/pubmed/id/12176031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-8-14
pubmed:abstractText
We examined the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on human cytomegalovirus (CMV) replication in the human embryonic fibroblast cell line, MRC-5. Treatment of cells with 0.0001pg/ml TCDD augmented the cytopathic effects of CMV-infected MRC-5 cells. Moreover, TCDD increased the replication of intracellular CMV without affecting the proliferation of host cells, with a concomitant increase in CMV UL54 DNA levels. However, TCDD demonstrated no virocidal effect on cell-free CMV. Furthermore, CMV-infected MRC-5 cells expressed transcripts of the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator. These results suggest that TCDD may contribute to the development of opportunistic diseases by reactivation of latently infected CMV and that TCDD regulates CMV replication through the dependence on AhR.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
296
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
651-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
2,3,7,8-Tetrachlorodibenzo-p-dioxin is a possible activator of human cytomegalovirus replication in a human fibroblast cell line.
pubmed:affiliation
Division of Persistent and Oncogenic Viruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, Japan. t-mura@m3.kufm.kagoshima-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't