Linked Life Data

12174816

Source:http://linkedlifedata.com/resource/pubmed/id/12174816

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-8-14
pubmed:abstractText
Besides motor, vegetative, and cognitive signs, patients suffering from Parkinson's disease (PD) may show distinct perceptual deficits such as underestimation of time intervals extending across several seconds. Assuming this impairment also to affect the domain of tens of milliseconds, disrupted encoding of the acoustic speech signal with respect to segment durations conveying linguistic information must be expected. To test this hypothesis, 10 PD patients and matched controls performed an identification task using a series of 10 stimuli derived from the utterance "Boten" (/bo:tn/, 'messengers'; produced with nasal plosion) by exclusive manipulation of occlusion length (110-20 ms in steps of 10 ms). Under these conditions, word-medial silence cues the voicing category of the respective stop consonant. Seven PD subjects showed normal identification curves, i.e., categorized the shortest and longest stimuli with high probability each as the minimal pair cognates "Boden" and "Boten," respectively. In contrast, the remaining three patients labeled all items across the complete range of occlusion lengths as "Boden." A subsequent experiment found a horizontal shift of the identification curves toward larger signal durations (> 120 ms) in these three subjects. Bilateral cerebellar degeneration has been found to yield a different response pattern, i.e., near-chance level of performance. Considering recent information-processing models of scalar interval timing, striatal disorders seem to slow down an oscillatory pacemaker, whereas cerebellar dysfunctions may impair comparison of measured durations with stored reference memory traces.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0093-934X
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-74
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Speech perception deficits in Parkinson's disease: underestimation of time intervals compromises identification of durational phonetic contrasts.
pubmed:affiliation
Department of Neurology, University of Tübingen, Germany.
pubmed:publicationType
Journal Article