Linked Life Data

121747

Source:http://linkedlifedata.com/resource/pubmed/id/121747

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1980-11-24
pubmed:abstractText
Female marmoset monkeys that are actively immunised against hCG beta-subunit remain infertile while antibody titres are high. With declining antibody levels the animals experience recurrent abortions that occur progressively later as the levels continue to wane. After booster immunisations the animals become infertile once more. The affinity and total binding sites of antibodies to beta-hCG were monitored after booster injections in marmosets and the values were correlated with subsequent reproductive events. The relationship between antibody amount and affinity varied considerably and the affinity was the important factor in producing the biological effects, pregnancies being often associated with a fall in antibody affinity. The antisera were also biologically active in inhibiting hCG-induced ovulation and increase in uterine weight in mice. There was no apparent cross-reaction between the antisera and human luteinizing hormone as tested by indirect immunofluorescence on adult human pituitary sections.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0165-0378
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
263-73
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Characterisation of the immunological response in marmoset monkeys immunised against hCG beta-subunit and its relationship with their subsequent fertility.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.