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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2002-8-12
pubmed:abstractText
In extrahepatic bile duct cancer, preoperative evaluation is important because only surgical excision of all detectable tumours is associated with improvement in 5-year survival. However, morphological imaging techniques, including computed tomography (CT), are still insufficient for accurate staging. The purpose of this study was to assess the additional value, in relation to CT, of 2-[(18)F]fluoro-2-deoxy- D-glucose positron emission tomography ((18)F-FDG PET) for the evaluation of extrahepatic bile duct cancer. Thirty patients with extrahepatic bile duct cancer underwent both (18)F-FDG PET and CT for initial staging. The results of the two modalities for evaluation of primary tumours and regional lymph nodes were compared with the final diagnoses based on pathological or clinical findings. The primary tumours were interpreted as malignant on the basis of CT in 24 (80%) of the patients, while (18)F-FDG PET revealed increased (18)F-FDG uptake in 18 (60%) of them. On the other hand, (18)F-FDG PET showed focal accumulation of (18)F-FDG in the bile duct in three of the six patients with equivocal findings on CT. The sensitivity, specificity and accuracy of CT for regional lymph node metastases were 54%, 59% and 57%, while those of (18)F-FDG PET were 38%, 100% and 73%, respectively. The specificity of (18)F-FDG PET for regional lymph node metastases was significantly higher than that of CT ( P<0.01). Of 14 patients with N1 or N2 disease diagnosed by CT, only seven (50%) had a final diagnosis of regional lymph node metastasis. In these 14 patients, (18)F-FDG PET accurately evaluated the N component of the disease in 12 patients (86%). In conclusion, in the initial staging of patients with extrahepatic bile duct cancer, (18)F-FDG PET offers additional value in relation to CT in evaluating both the primary tumour and regional lymph nodes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1619-7070
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1047-54
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12173019-Adenocarcinoma, pubmed-meshheading:12173019-Adult, pubmed-meshheading:12173019-Aged, pubmed-meshheading:12173019-Aged, 80 and over, pubmed-meshheading:12173019-Bile Duct Neoplasms, pubmed-meshheading:12173019-Bile Ducts, Extrahepatic, pubmed-meshheading:12173019-Carcinoma, Adenosquamous, pubmed-meshheading:12173019-Carcinoma, Squamous Cell, pubmed-meshheading:12173019-Female, pubmed-meshheading:12173019-Fluorodeoxyglucose F18, pubmed-meshheading:12173019-Humans, pubmed-meshheading:12173019-Lymphatic Metastasis, pubmed-meshheading:12173019-Male, pubmed-meshheading:12173019-Middle Aged, pubmed-meshheading:12173019-Neoplasm Staging, pubmed-meshheading:12173019-Radiopharmaceuticals, pubmed-meshheading:12173019-Reproducibility of Results, pubmed-meshheading:12173019-Sensitivity and Specificity, pubmed-meshheading:12173019-Tomography, Emission-Computed
pubmed:year
2002
pubmed:articleTitle
Clinical role of (18)F-FDG PET for initial staging of patients with extrahepatic bile duct cancer.
pubmed:affiliation
Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 6, Kita-ku, Sapporo 060-8638, Japan.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Evaluation Studies