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pubmed-article:12171966pubmed:abstractTextA homozygous mutation of the endothelin B receptor (EDNRB) gene in spotting lethal (sl/sl) rats leads to Hirschsprung's disease (HSCR) with long segmented aganglionosis. However, the effects on the development of the enteric nervous system (ENS) promoted by a heterozygous mutation of the EDNRB gene are not known. The present study aimed to describe and morphometrically assess the phenotypic abnormalities of the ENS in heterozygous (+/sl) EDNRB deficient rats in comparison with homozygous (sl/sl) EDNRB deficient and wild-type (+/+) rats.lld:pubmed
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pubmed-article:12171966pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:12171966pubmed:articleTitleAbnormalities of the enteric nervous system in heterozygous endothelin B receptor deficient (spotting lethal) rats resembling intestinal neuronal dysplasia.lld:pubmed
pubmed-article:12171966pubmed:affiliationDepartment of Medicine II (Gastroenterology), University Hospital of Heidelberg at Mannheim, Germany.lld:pubmed
pubmed-article:12171966pubmed:publicationTypeJournal Articlelld:pubmed