rdf:type |
|
lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-8-12
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pubmed:abstractText |
A homozygous mutation of the endothelin B receptor (EDNRB) gene in spotting lethal (sl/sl) rats leads to Hirschsprung's disease (HSCR) with long segmented aganglionosis. However, the effects on the development of the enteric nervous system (ENS) promoted by a heterozygous mutation of the EDNRB gene are not known. The present study aimed to describe and morphometrically assess the phenotypic abnormalities of the ENS in heterozygous (+/sl) EDNRB deficient rats in comparison with homozygous (sl/sl) EDNRB deficient and wild-type (+/+) rats.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0017-5749
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
414-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12171966-Animals,
pubmed-meshheading:12171966-Cecum,
pubmed-meshheading:12171966-Colon,
pubmed-meshheading:12171966-Enteric Nervous System,
pubmed-meshheading:12171966-Heterozygote,
pubmed-meshheading:12171966-Ileum,
pubmed-meshheading:12171966-Intestinal Diseases,
pubmed-meshheading:12171966-Intestine, Small,
pubmed-meshheading:12171966-Peripheral Nervous System Diseases,
pubmed-meshheading:12171966-Phenotype,
pubmed-meshheading:12171966-Rats,
pubmed-meshheading:12171966-Rats, Wistar,
pubmed-meshheading:12171966-Receptor, Endothelin B,
pubmed-meshheading:12171966-Receptors, Endothelin
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pubmed:year |
2002
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pubmed:articleTitle |
Abnormalities of the enteric nervous system in heterozygous endothelin B receptor deficient (spotting lethal) rats resembling intestinal neuronal dysplasia.
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pubmed:affiliation |
Department of Medicine II (Gastroenterology), University Hospital of Heidelberg at Mannheim, Germany.
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pubmed:publicationType |
Journal Article
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