12171906

Source:http://linkedlifedata.com/resource/pubmed/id/12171906

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017638, umls-concept:C0076080, umls-concept:C0683598
pubmed:issue	8
pubmed:dateCreated	2002-8-12
pubmed:abstractText	The contributions of O6-methylguanine-DNA-methyltransferase(MGMT), p53 status, mismatch repair, and apoptotic response to the resistance of glial tumors to temozolomide (TMZ) were tested using seven established human glial tumor cell lines in culture and xenografts in athymic mice.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA 57725, http://linkedlifedata.com/resource/pubmed/grant/CA 78561, http://linkedlifedata.com/resource/pubmed/grant/CA84461
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9502500
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating, http://linkedlifedata.com/resource/pubmed/chemical/Dacarbazine, http://linkedlifedata.com/resource/pubmed/chemical/Thioguanine, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53, http://linkedlifedata.com/resource/pubmed/chemical/temozolomide
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	1078-0432
pubmed:author	pubmed-author:BhakatKishor KKK, pubmed-author:BocangelDora BDB, pubmed-author:FinkelsteinSydneyS, pubmed-author:KokkinakisDemetrius MDM, pubmed-author:MitraSankarS, pubmed-author:ScholdS CliffordSC
pubmed:issnType	Print
pubmed:volume	8
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2725-34
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:12171906-Alleles, pubmed-meshheading:12171906-Animals, pubmed-meshheading:12171906-Antineoplastic Agents, Alkylating, pubmed-meshheading:12171906-Apoptosis, pubmed-meshheading:12171906-Base Pair Mismatch, pubmed-meshheading:12171906-Blotting, Western, pubmed-meshheading:12171906-Brain Neoplasms, pubmed-meshheading:12171906-Cell Cycle, pubmed-meshheading:12171906-Cell Nucleus, pubmed-meshheading:12171906-Cytosol, pubmed-meshheading:12171906-DNA Damage, pubmed-meshheading:12171906-DNA Repair, pubmed-meshheading:12171906-Dacarbazine, pubmed-meshheading:12171906-Drug Resistance, Neoplasm, pubmed-meshheading:12171906-Glioma, pubmed-meshheading:12171906-Humans, pubmed-meshheading:12171906-Immunohistochemistry, pubmed-meshheading:12171906-In Situ Nick-End Labeling, pubmed-meshheading:12171906-Mice, pubmed-meshheading:12171906-Mice, Inbred BALB C, pubmed-meshheading:12171906-Mice, Nude, pubmed-meshheading:12171906-Neoplasm Transplantation, pubmed-meshheading:12171906-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:12171906-Sequence Analysis, DNA, pubmed-meshheading:12171906-Thioguanine, pubmed-meshheading:12171906-Time Factors, pubmed-meshheading:12171906-Tumor Cells, Cultured, pubmed-meshheading:12171906-Tumor Suppressor Protein p53
pubmed:year	2002
pubmed:articleTitle	Multifaceted resistance of gliomas to temozolomide.
pubmed:affiliation	Department of Pathology, The University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15261, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S.