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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-8-12
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pubmed:abstractText |
The present study was designed to investigate the nature of the 5-HT4 receptors affecting the peristaltic reflex in the isolated rat distal colon. A single peristaltic reflex was evoked by infusing Tyrode solution into the lumen of the isolated segment using our modified Trendelenburg's method under an isovolumic condition. A 5-HT4 receptor agonist, mosapride (10 nM), did not affect the threshold pressure and the propagation distance of the reflex contraction, but significantly increased the developed pressure (maximum pressure - threshold pressure) from 19.1 +/- 11.8 cm H2O in the control to 26.8 +/- 13.0 cm H2O (n = 8, P<0.05) without affecting the resting muscle tone in the distal colon. The present result suggests that stimulation of 5-HT4 receptor enhances the propulsive power to move the luminal contents in the rat distal colon.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1566-0702
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
62-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12171259-Animals,
pubmed-meshheading:12171259-Benzamides,
pubmed-meshheading:12171259-Colon,
pubmed-meshheading:12171259-Dose-Response Relationship, Drug,
pubmed-meshheading:12171259-Enteric Nervous System,
pubmed-meshheading:12171259-Male,
pubmed-meshheading:12171259-Morpholines,
pubmed-meshheading:12171259-Muscle, Smooth,
pubmed-meshheading:12171259-Muscle Contraction,
pubmed-meshheading:12171259-Muscle Tonus,
pubmed-meshheading:12171259-Neurons,
pubmed-meshheading:12171259-Peristalsis,
pubmed-meshheading:12171259-Pressure,
pubmed-meshheading:12171259-Rats,
pubmed-meshheading:12171259-Rats, Wistar,
pubmed-meshheading:12171259-Receptors, Serotonin,
pubmed-meshheading:12171259-Receptors, Serotonin, 5-HT4,
pubmed-meshheading:12171259-Reflex, Stretch,
pubmed-meshheading:12171259-Serotonin,
pubmed-meshheading:12171259-Serotonin Receptor Agonists,
pubmed-meshheading:12171259-Up-Regulation
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pubmed:year |
2002
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pubmed:articleTitle |
5-HT4 receptor enhances the propulsive power of the peristaltic reflex in the rat distal colon.
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pubmed:affiliation |
Department of Physiology II, Nara Medical University, Kashihara, Japan. makotok@naramed-u.ac.jp
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pubmed:publicationType |
Journal Article
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