Linked Life Data

12170599

Source:http://linkedlifedata.com/resource/pubmed/id/12170599

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-8-12
pubmed:abstractText
Nicotinamide adenine dinucleotide fluorescence, cortical reflectance, cortical blood flow, and electroencephalograms were recorded from squirrel monkey brains before, during, and after focal transient cerebral ischemia produced by the temporary clipping of the middle cerebral artery. After release of the occluding clip, the monkeys were followed through an N2-breathing cycle and then to death from anoxia. The effects of controlled variations in arterial carbon dioxide tensions (PaCO2) and mean arterial blood pressures (MABP) were investigated in normal and in ischemic brain. In normal brain, with preserved autoregulation, NADH fluorescence was constant through a wide range in Paco2, MABP, and cortical blood flow. In ischemic brain, NADH levels increased, correlated closely with decreased cortical blood flow and EEG abnormalities, and became dependent on MABP. Artifacts in fluorescent measurements were reduced by: monochromators for excitation, emission, and reflected light; low intensity vertical excitation energy and high sensitivity recording instrumentation; and a small avascular (123 microns) field.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-3042
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1125-33
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Effect of hypocapnia, hypercapnia, and blood pressure on NADH fluorescence, electrical activity, and blood flow in normal and partially ischemic monkey cortex.
pubmed:affiliation
Cerebrovascular Clinical Research Center, Mayo Clinic, Mayo Foundation, Rochester, MN 55901, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.