Linked Life Data

12165411

Source:http://linkedlifedata.com/resource/pubmed/id/12165411

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-8-7
pubmed:abstractText
The expression of adrenomedullin (AM) was studied in the caudate-putamen of the adult rat brain using a global cerebral ischaemia model. The animals were subjected to 30 min of glucose and oxygen deprivation, and the brains were collected after 0, 2, 4, 6, 8 and 10 h of reperfusion. Coronal sections of the caudate-putamen were studied by immunocytochemistry using a specific polyclonal antibody against AM and examined by light microscopy. Under these experimental conditions AM immunoreactivity increased in the wall of the blood vessels and in three different types of neurons distributed throughout the caudate-putamen. Our findings suggest that the over-expression of AM and its changes in its intracellular location might be involved in the neuronal responses to brain ischaemia with a possible neuroprotector role.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0304-3940
pubmed:author
pubmed:copyrightInfo
Copyright 2002 Elsevier Science Ireland Ltd.
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
329
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-200
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Adrenomedullin over-expression in the caudate-putamen of the adult rat brain after ischaemia-reperfusion injury.
pubmed:affiliation
Department of Neuroanatomy and Cell Biology, Instituto de Neurobiología Ramón y Cajal, CSIC, Avenida Doctor del Arce 37, 28002 Madrid, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't