Linked Life Data

12164590

Source:http://linkedlifedata.com/resource/pubmed/id/12164590

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2002-8-7
pubmed:abstractText
An x-ray fluorescence system with a synchrotron radiation source was used to quantify the levels of iron, copper and zinc in breast tissue specimens. Healthy tissue and breast carcinomas were investigated as an aid to understanding the mechanisms of breast cancer and as a possible complementary diagnostic tool. Eighty samples were measured in total. Twenty samples were matched pairs, i.e. 20 tumour samples with 20 corresponding healthy tissue specimens taken at a distance from the tumour. The remaining 40 samples consisted of 20 excised tumours and 20 healthy specimens from breast reduction surgeries. The levels of the elements of interest were quantified via calibration models constructed using the XRF response from standard solutions. The statistical analysis of the results indicates elevation of the levels of all three trace elements in the tumours. The effect is more prominent for copper and zinc while the contrast between healthy and diseased tissue is enhanced when comparing the independent specimens rather than the paired samples. Specifically, the ratio of mean tumour to mean healthy concentration for iron was 1.6 for the paired samples and 2.7 for the non-paired samples. The ratios describing copper content were 3.1 for paired and 3.6 for non-paired samples while for zinc they were 2.4 and 4.4 respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0031-9155
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2327-39
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Concentrations of Fe, Cu and Zn in breast tissue: a synchrotron XRF study.
pubmed:affiliation
Department of Radiography, City University, London, UK.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't