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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2002-8-7
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pubmed:abstractText |
Transforming growth factor-beta 1 (TGF-beta1)is a polypeptide growth factor which has been shown to increase bone formation in experimental studies. In this study it was combined to a bioabsorbable self-reinforced poly-LD-lactic acid fracture fixation pin. To assess the effect of TGF-beta1 on the healing of a bone defect, the pins were implanted in the rat distal femur next to a bone defect filled with a viscose cellulose sponge. The pins used in the study group (13 rats) contained 50 microg of TGF-beta1, whereas in the control group of nine rats an identical pin without the growth factor was used. In the histologic examination at 1, 3 and 6 weeks no difference was detected in the amount of bone inside the viscose cellulose sponge between the rats treated with TGF-beta1 and those with no added growth factor. At 3 weeks there was more fibroblast-rich mesenchymal tissue inside the viscose cellulose sponge in the rats treated with TGF-beta1. In the radiographic examination at 3 weeks there was an increase in the amount of new periosteal bone on the bone defect in the TGF-beta1-treated rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Cellulose,
http://linkedlifedata.com/resource/pubmed/chemical/Coated Materials, Biocompatible,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/poly(lactic acid)
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0142-9612
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3817-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12164185-Absorbable Implants,
pubmed-meshheading:12164185-Animals,
pubmed-meshheading:12164185-Biocompatible Materials,
pubmed-meshheading:12164185-Bone Nails,
pubmed-meshheading:12164185-Bone and Bones,
pubmed-meshheading:12164185-Cellulose,
pubmed-meshheading:12164185-Coated Materials, Biocompatible,
pubmed-meshheading:12164185-Femoral Fractures,
pubmed-meshheading:12164185-Fracture Fixation, Internal,
pubmed-meshheading:12164185-Fracture Healing,
pubmed-meshheading:12164185-Lactic Acid,
pubmed-meshheading:12164185-Male,
pubmed-meshheading:12164185-Polymers,
pubmed-meshheading:12164185-Rats,
pubmed-meshheading:12164185-Rats, Wistar,
pubmed-meshheading:12164185-Time Factors,
pubmed-meshheading:12164185-Transforming Growth Factor beta,
pubmed-meshheading:12164185-Transforming Growth Factor beta1
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pubmed:year |
2002
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pubmed:articleTitle |
The effect of transforming growth factor-beta1, released from a bioabsorbable self-reinforced polylactide pin, on a bone defect.
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pubmed:affiliation |
Department of Surgery, Helsinki University Hospital, Finland. laura.tielinen@hus.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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