rdf:type |
|
lifeskim:mentions |
umls-concept:C0002721,
umls-concept:C0026809,
umls-concept:C0228174,
umls-concept:C0333562,
umls-concept:C0380603,
umls-concept:C0442118,
umls-concept:C1100714,
umls-concept:C1167624,
umls-concept:C1515655,
umls-concept:C1548779,
umls-concept:C1947902,
umls-concept:C2827499
|
pubmed:issue |
8
|
pubmed:dateCreated |
2002-8-6
|
pubmed:abstractText |
There is currently no method for noninvasive imaging of amyloid beta (Abeta) deposition in Alzheimer's disease (AD). Because Abeta plaques are characteristic of AD and Abeta deposits contain abundant heparan sulfate proteoglycans that can bind basic fibroblast growth factor (bFGF) and serum amyloid P component (SAP), we investigated a novel route of ligand delivery to the brain to assess Abeta deposition in a transgenic (Tg) mouse model overexpressing Abeta-protein precursor.
|
pubmed:grant |
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0161-5505
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
43
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1044-51
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:12163630-Administration, Intranasal,
pubmed-meshheading:12163630-Alzheimer Disease,
pubmed-meshheading:12163630-Amyloid beta-Peptides,
pubmed-meshheading:12163630-Animals,
pubmed-meshheading:12163630-Brain,
pubmed-meshheading:12163630-Fibroblast Growth Factor 2,
pubmed-meshheading:12163630-Humans,
pubmed-meshheading:12163630-Iodine Radioisotopes,
pubmed-meshheading:12163630-Male,
pubmed-meshheading:12163630-Mice,
pubmed-meshheading:12163630-Mice, Transgenic,
pubmed-meshheading:12163630-Microscopy, Electron,
pubmed-meshheading:12163630-Serum Amyloid P-Component,
pubmed-meshheading:12163630-Tissue Distribution
|
pubmed:year |
2002
|
pubmed:articleTitle |
Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice.
|
pubmed:affiliation |
Department of Neurology, Case Western Reserve University, University Hospitals of Cleveland, Ohio 44106-4962, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|