| pubmed-article:12163482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12163482 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12163482 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:12163482 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:12163482 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:12163482 | lifeskim:mentions | umls-concept:C0034786 | lld:lifeskim |
| pubmed-article:12163482 | lifeskim:mentions | umls-concept:C0034840 | lld:lifeskim |
| pubmed-article:12163482 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12163482 | pubmed:issue | 41 | lld:pubmed |
| pubmed-article:12163482 | pubmed:dateCreated | 2002-10-7 | lld:pubmed |
| pubmed-article:12163482 | pubmed:abstractText | The androgen receptor (AR) can be activated in the absence of androgens by interleukin-6 (IL-6) in human prostate cancer cells. The events involved in ligand-independent activation of the AR are unknown, but have been suggested to involve phosphorylation of the AR itself or a receptor-associated protein. Steroid receptor coactivator-1 (SRC-1) has been shown to interact with the human AR and to modulate ligand-dependent AR transactivation and is regulated by phosphorylation by MAPK. To date, no one has examined the role of SRC-1 in ligand-independent activation of the AR by IL-6 or other signaling pathways known to activate the full-length receptor. This study addressed this and has revealed the following. 1) SRC-1 similarly enhanced ligand-independent activation of the AR by IL-6 to the same magnitude as that obtained via ligand-dependent activation. 2) Androgen and IL-6 stimulated the MAPK pathway. 3) MAPK was required for both ligand-dependent and ligand-independent activation of the AR. 4) Phosphorylation of SRC-1 by MAPK was required for optimal ligand-independent activation of the AR by IL-6. 5) Protein-protein interaction between endogenous AR and SRC-1 was dependent upon treatment of LNCaP cells with IL-6 or R1881. 6) Protein-protein interaction between the AR N-terminal domain and SRC-1 was independent of MAPK. 7) Ligand-independent activation of the AR did not occur by a mechanism of overexpression of either solely wild-type SRC-1 or mutant SRC-1 that mimics its phosphorylated form. | lld:pubmed |
| pubmed-article:12163482 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12163482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163482 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12163482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12163482 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12163482 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12163482 | pubmed:author | pubmed-author:UedaTakeshiT | lld:pubmed |
| pubmed-article:12163482 | pubmed:author | pubmed-author:BruchovskyNic... | lld:pubmed |
| pubmed-article:12163482 | pubmed:author | pubmed-author:SadarMarianne... | lld:pubmed |
| pubmed-article:12163482 | pubmed:author | pubmed-author:MawjiNasrin... | lld:pubmed |
| pubmed-article:12163482 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12163482 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:12163482 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:12163482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12163482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12163482 | pubmed:pagination | 38087-94 | lld:pubmed |
| pubmed-article:12163482 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12163482 | pubmed:meshHeading | pubmed-meshheading:12163482... | lld:pubmed |
| pubmed-article:12163482 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12163482 | pubmed:articleTitle | Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. | lld:pubmed |
| pubmed-article:12163482 | pubmed:affiliation | Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 4E6, Canada. | lld:pubmed |
| pubmed-article:12163482 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12163482 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12163482 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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