| pubmed-article:12163055 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12163055 | lifeskim:mentions | umls-concept:C0242275 | lld:lifeskim |
| pubmed-article:12163055 | lifeskim:mentions | umls-concept:C0023467 | lld:lifeskim |
| pubmed-article:12163055 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:12163055 | lifeskim:mentions | umls-concept:C0934502 | lld:lifeskim |
| pubmed-article:12163055 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:12163055 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:12163055 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12163055 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:12163055 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:12163055 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:12163055 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12163055 | pubmed:dateCreated | 2002-8-6 | lld:pubmed |
| pubmed-article:12163055 | pubmed:abstractText | The hematopoietic supporting abilities are known to be impaired in marrow stromal layers developed from patients with acute myeloid leukemia (AML). In this study, fibroblast growth factor-4 (FGF-4), epidermal growth factor (EGF) or transforming growth factor-beta1 (TGF-beta1) were studied to see whether these growth factors can modify the functional development of leukemic stromal layers. Adherent stromal layers from 13 patients with AML and from six non-leukemic controls were established with 3ng/ml of FGF-4, EGF or TGF-beta1. Established stromal layers were washed three times and irradiated, followed by recharge of allogenic peripheral CD34 positive cells as an indicator of supportive function. Progenitor-outputs into supernatant were evaluated at biweekly interval with colony-forming assay until 6 weeks. The results showed that both leukemic and non-leukemic stromal cells established with FGF-4, but not with EGF, showed significantly higher progenitor cell-outputs compared with control stromal cells. By contrast, stromal cells developed with TGF-beta1 showed significantly lower progenitor cell-outputs compared with control. These differences were significant at later than 4 weeks after the recharge of indicator cells, suggesting that the stromal layer developed with EGF or TGF-beta1 preferentially affected the primitive progenitors rather than committed ones. These results indicate that FGF-4 and TGF-beta1 differentially affect the functional development of leukemic as well as of normal stromal layers. | lld:pubmed |
| pubmed-article:12163055 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12163055 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163055 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12163055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163055 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12163055 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12163055 | pubmed:issn | 0145-2126 | lld:pubmed |
| pubmed-article:12163055 | pubmed:author | pubmed-author:YamaneTakahis... | lld:pubmed |
| pubmed-article:12163055 | pubmed:author | pubmed-author:HinoMasayukiM | lld:pubmed |
| pubmed-article:12163055 | pubmed:author | pubmed-author:OhtaKensukeK | lld:pubmed |
| pubmed-article:12163055 | pubmed:author | pubmed-author:TatsumiNoriyu... | lld:pubmed |
| pubmed-article:12163055 | pubmed:author | pubmed-author:TakuboTakayuk... | lld:pubmed |
| pubmed-article:12163055 | pubmed:author | pubmed-author:KohKi-RyangKR | lld:pubmed |
| pubmed-article:12163055 | pubmed:author | pubmed-author:NakamaeHirohi... | lld:pubmed |
| pubmed-article:12163055 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12163055 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:12163055 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12163055 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12163055 | pubmed:pagination | 933-8 | lld:pubmed |
| pubmed-article:12163055 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12163055 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12163055 | pubmed:articleTitle | Differential effects of fibroblast growth factor-4, epidermal growth factor and transforming growth factor-beta1 on functional development of stromal layers in acute myeloid leukemia. | lld:pubmed |
| pubmed-article:12163055 | pubmed:affiliation | Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University, 1-4-3, Asahimachi, Abeno-ku, Osaka, Japan. | lld:pubmed |
| pubmed-article:12163055 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12163055 | pubmed:publicationType | Comparative Study | lld:pubmed |
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