Source:http://linkedlifedata.com/resource/pubmed/id/12163024
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2002-8-6
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pubmed:abstractText |
We previously reported that the peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) mRNA in rat epitrochlearis muscle was increased after swimming exercise training. In the present study, we demonstrated further that PGC-1 mRNA expression in the epitrochlearis muscle of 4-5-week-old male Sprague-Dawley rats was increased after a 6-h acute bout of low-intensity swimming exercise. With this increase, the expression level was approximately 8-fold of control and immersion group rats that stayed for 6-h in warm water, maintained at the identical temperature of the swimming barrel (35 degrees C) (p<0.01). Second, PGC-1 mRNA expression in the muscle was found to have increased 6-h after 30 10-s tetani contractions were induced by in vitro electrical stimulation. Finally, PGC-1 mRNA expression in the muscle incubated for 18-h with 0.5mM 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR: a 5' AMP-activated protein kinase (AMPK) activator) was elevated to approximately 3-fold of the control muscle (n=6, p<0.001). AMPK activity in epitrochlearis muscle after the swimming was also found to be elevated to approximately 4-fold of the pre-exercise value (p<0.001). These results may suggest that an acute bout of low-intensity prolonged swimming exercise directly enhances the PGC-1 mRNA expression in the activated muscle during exercise, possibly through, at least in part, an AMPK-related mechanism.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AMP-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Aminoimidazole Carboxamide,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleosides,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/acadesine,
http://linkedlifedata.com/resource/pubmed/chemical/peroxisome-proliferator-activated...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
296
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
350-4
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12163024-AMP-Activated Protein Kinases,
pubmed-meshheading:12163024-Aminoimidazole Carboxamide,
pubmed-meshheading:12163024-Animals,
pubmed-meshheading:12163024-Electric Stimulation,
pubmed-meshheading:12163024-Enzyme Activation,
pubmed-meshheading:12163024-Male,
pubmed-meshheading:12163024-Multienzyme Complexes,
pubmed-meshheading:12163024-Muscle, Skeletal,
pubmed-meshheading:12163024-Muscle Contraction,
pubmed-meshheading:12163024-Physical Conditioning, Animal,
pubmed-meshheading:12163024-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12163024-Rats,
pubmed-meshheading:12163024-Rats, Sprague-Dawley,
pubmed-meshheading:12163024-Ribonucleosides,
pubmed-meshheading:12163024-Swimming,
pubmed-meshheading:12163024-Transcription Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle.
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pubmed:affiliation |
Laboratory of Exercise Physiology, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku City, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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