Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1976-4-29
|
| pubmed:abstractText |
The effect of diethylstilbestrol (DES) on the percent conversion of a 14C-progesterone (14C-P) substrate to 14C-testosterone (14C-T) when added to incubates fo rat testicular homogenates has been measured. Similarly the effect of DES administered parenterally to intact adult rats at 9 dose regimens on such conversion has been evaluated. In addition, in the latter group serum luteinizing hormone (LH) levels were assessed simultaneously. DES added in-vitro significantly reduced T formation at every level. Only the large parenteral dose of DES affected T synthesis after 24 hours, while every parenteral dose significantly reduced T synthesis with 4 and 8 day regimens. Mean serum LH levels failed to reflect a significant decrease at the 1 and 4 day dose level, but did decrease significantly in 2 of 3 groups on the 8 day regimen. These results suggest that there is a direct effect of DES at a testicular level inhibiting T synthesis not associated with a simultaneous drop in mean serum LH levels. A measurable decrease in LH concentration does occur with continued treatment.
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Androgens,
http://linkedlifedata.com/resource/pubmed/keyword/Animals, Laboratory,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Estrogen,
http://linkedlifedata.com/resource/pubmed/keyword/Diethylstilbestrol--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Estrogens,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia, Male,
http://linkedlifedata.com/resource/pubmed/keyword/Gonadotropins,
http://linkedlifedata.com/resource/pubmed/keyword/Gonadotropins, Pituitary,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/In Vitro,
http://linkedlifedata.com/resource/pubmed/keyword/Injectables,
http://linkedlifedata.com/resource/pubmed/keyword/Luteinizing Hormone--analysis,
http://linkedlifedata.com/resource/pubmed/keyword/PROGESTERONE,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Progestational Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Testis,
http://linkedlifedata.com/resource/pubmed/keyword/Testosterone--analysis,
http://linkedlifedata.com/resource/pubmed/keyword/Urogenital System
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0039-128X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
797-806
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:otherAbstract |
PIP: The effect of diethylstilbestrol (DES) on the conversion of carbon-14-progesterone to carbon-14-testosterone in incubates of rat testicular homogenates was studied, as well as the in vivo effect of DES, administered parenterally, on the conversion of the hormones and levels of luteinizing hormone (LH). In vitro, DES significantly diminished testosterone formation at every dose level (p.01). DES, administered in repeated daily doses for 4 or 8 days, caused a markedly decreasing conversion to testosterone. The 1- and 4-day dose levels of DES did not produce significant changes in LH levels (p .1), though an 8-day regimen of 5 mg and 50 mg DES significantly decreased LH values (p .02, p .02, respectively). It is suggested that DES has a direct effect, at the testicular level, in inhibiting the synthesis of testosterone, which is not associated with a drop in serum LH levels.
|
| pubmed:meshHeading |
pubmed-meshheading:1216262-Animals,
pubmed-meshheading:1216262-Diethylstilbestrol,
pubmed-meshheading:1216262-Male,
pubmed-meshheading:1216262-Progesterone,
pubmed-meshheading:1216262-Rats,
pubmed-meshheading:1216262-Testis,
pubmed-meshheading:1216262-Testosterone,
pubmed-meshheading:1216262-Time Factors
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
The in-vitro and in-vito effects of diethylstilbestrol on testicular synthesis of testosterone.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|