Linked Life Data

12161702

Source:http://linkedlifedata.com/resource/pubmed/id/12161702

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-8-5
pubmed:abstractText
Physiological changes that occur in the aging process may directly affect drug pharmacokinetics. In the absence of disease or other pathologic conditions, age-related changes in pharmacokinetics principally affect drug absorption, distribution, metabolism or elimination. One factor that does change consistently with age is renal clearance, consequently a common pharmacokinetic change is reduced drug clearance, especially for drugs excreted largely unchanged by the kidneys. Alteration of the pharmacokinetics of drugs in the elderly may necessitate adjustment of dosages to prevent toxicity or inadequate therapy. As a broad generalization, dosage should be reduced in elderly patients, reflecting the general decline in body function with age.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0761-8425
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
356-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
[Pharmacokinetics in the elderly].
pubmed:affiliation
Département de Pharmacologie, CHU Pellegrin-Carreire, Bordeaux, France.
pubmed:publicationType
Journal Article, English Abstract, Review