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rdf:type |
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lifeskim:mentions |
umls-concept:C0013604,
umls-concept:C0027893,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0081937,
umls-concept:C0205100,
umls-concept:C0333348,
umls-concept:C0597357,
umls-concept:C0687080,
umls-concept:C1280500,
umls-concept:C1314939,
umls-concept:C1704675
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pubmed:issue |
1-2
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pubmed:dateCreated |
2002-8-5
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pubmed:abstractText |
Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw edema in the rat. The NPY Y1 receptor antagonist BIBO 3304 abolishes the pro-inflammatory action of both NPY and PYY while the dipeptidyl-peptidase IV (CD26) inhibitor Ile-thiazolidide exerted synergistic and potentiating effects in vivo. Taken together, the present data reveal an NPY Y1/Y5 receptor interplay and an involvement of CD26 in the NPY-induced potentiation of paw edema in the rat.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/BIBO 3304,
http://linkedlifedata.com/resource/pubmed/chemical/Concanavalin A,
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptidyl Peptidase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Isoleucine,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptide Y,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide YY,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neuropeptide Y,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/isoleucyl-thiazolidide,
http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y, Leu(31)-Pro(34)-,
http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y (13-36),
http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y (3-36),
http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y-Y1 receptor,
http://linkedlifedata.com/resource/pubmed/chemical/neuropeptide Y5 receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35-42
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12161018-Animals,
pubmed-meshheading:12161018-Arginine,
pubmed-meshheading:12161018-Cells, Cultured,
pubmed-meshheading:12161018-Concanavalin A,
pubmed-meshheading:12161018-Dipeptidyl Peptidase 4,
pubmed-meshheading:12161018-Dose-Response Relationship, Drug,
pubmed-meshheading:12161018-Edema,
pubmed-meshheading:12161018-Hydrogen Peroxide,
pubmed-meshheading:12161018-Inflammation,
pubmed-meshheading:12161018-Isoleucine,
pubmed-meshheading:12161018-Macrophages,
pubmed-meshheading:12161018-Male,
pubmed-meshheading:12161018-Neuropeptide Y,
pubmed-meshheading:12161018-Peptide Fragments,
pubmed-meshheading:12161018-Peptide YY,
pubmed-meshheading:12161018-Rats,
pubmed-meshheading:12161018-Rats, Wistar,
pubmed-meshheading:12161018-Receptors, Neuropeptide Y,
pubmed-meshheading:12161018-Thiazoles
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pubmed:year |
2002
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pubmed:articleTitle |
Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPY Y1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26).
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pubmed:affiliation |
Immunology Research Center Branislav Jankovi?, Institute of Immunology and Virology "Torlak", Vojvode Stepe 458, 11152, Belgrade, Yugoslavia. ilijadim@EUnet.YU
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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