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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2002-8-2
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pubmed:abstractText |
Although it was known for a long time that oxygen deprivation leads to the transcriptional induction of the gene encoding erythropoietin, the molecular mechanisms behind this process remained enigmatic. The cloning of the hypoxia-inducible factors (HIFs), the finding that HIF-1 regulates the expression of many more genes apart from erythropoietin, and the elucidation of the oxygen-dependent mechanisms degrading the HIF alpha subunits recently led to the spectacular discovery of the molecular principles of oxygen sensing. This review aims to summarize our current knowledge of oxygen-regulated gene expression..
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ARNT protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Receptor Nuclear...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Aryl Hydrocarbon,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/VHL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Von Hippel-Lindau Tumor Suppressor...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1530-6860
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1151-62
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12153983-Adaptation, Physiological,
pubmed-meshheading:12153983-Animals,
pubmed-meshheading:12153983-Aryl Hydrocarbon Receptor Nuclear Translocator,
pubmed-meshheading:12153983-Cell Hypoxia,
pubmed-meshheading:12153983-DNA-Binding Proteins,
pubmed-meshheading:12153983-Glucose,
pubmed-meshheading:12153983-Humans,
pubmed-meshheading:12153983-Hypoxia-Inducible Factor 1,
pubmed-meshheading:12153983-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:12153983-Iron,
pubmed-meshheading:12153983-Ligases,
pubmed-meshheading:12153983-Mixed Function Oxygenases,
pubmed-meshheading:12153983-Nuclear Proteins,
pubmed-meshheading:12153983-Oxygen,
pubmed-meshheading:12153983-Receptors, Aryl Hydrocarbon,
pubmed-meshheading:12153983-Transcription Factors,
pubmed-meshheading:12153983-Transcriptional Activation,
pubmed-meshheading:12153983-Tumor Suppressor Proteins,
pubmed-meshheading:12153983-Ubiquitin-Protein Ligases,
pubmed-meshheading:12153983-Von Hippel-Lindau Tumor Suppressor Protein
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pubmed:year |
2002
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pubmed:articleTitle |
Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression.
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pubmed:affiliation |
Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany. wenr@medizin.uni-leipzig.de
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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