Linked Life Data

12153970

Source:http://linkedlifedata.com/resource/pubmed/id/12153970

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-8-2
pubmed:abstractText
Stenotrophomonas maltophilia is a gram-negative bacterium that has been cultured with increasing prevalence from the sputum of patients with cystic fibrosis (CF). We conducted a cohort study, using the Cystic Fibrosis Foundation Registry, to assess the effect of S. maltophilia on survival. We studied all patients in this registry from 1991 to 1997 who were older than 6 years of age, were S. maltophilia negative in the first year of enrollment, and had their CF diagnosed before the age of 45 years (n = 19,255 in the study). We compared patients who acquired S. maltophilia with those who did not, using survival analysis. A total of 1,673 (8.7%) had at least one sputum sample positive for S. maltophilia. Compared with patients without S. maltophilia, those patients positive for S. maltophilia had the following baseline characteristics before detection: lower FEV(1) % pred (p < 0.001); older (p = 0.001); more likely to be female (p = 0.003); and more pulmonary exacerbations (p < 0.001), outpatient visits (p < 0.002), and total hospitalizations (p < 0.001). After controlling for differences in severity of disease and coinfection with Pseudomonas aeruginosa, the hazard ratio associated with S. maltophilia detection was 0.89 (95% confidence interval, 0.75-1.05). Although patients with CF who acquire S. maltophilia have more advanced disease than those who do not acquire this organism, detection does not independently affect short-term survival (3 years).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1073-449X
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
166
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
356-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Detecting Stenotrophomonas maltophilia does not reduce survival of patients with cystic fibrosis.
pubmed:affiliation
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington Medical Center, Campus Box 356522, 1959 N.E. Pacific, Seattle, WA 98195, USA. goss@u.washington.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't