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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0085862,
umls-concept:C0086418,
umls-concept:C0105770,
umls-concept:C0591833,
umls-concept:C1299583,
umls-concept:C1334043,
umls-concept:C1367453,
umls-concept:C1422179,
umls-concept:C1549571,
umls-concept:C1608386,
umls-concept:C1879547
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pubmed:issue |
Pt 3
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pubmed:dateCreated |
2002-10-23
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pubmed:abstractText |
The Wnt signal transduction pathway regulates morphogenesis and mitogenesis of cells in multicellular organisms. A major downstream consequence of Wnt-1 signalling is the activation of beta-catenin/T-cell factor (TCF)-mediated transcription. We compared Wnt-1-transformed murine mammary epithelial cells with control cells by subtractive hybridization. We found the two genes Nr4a1 and Herpud1 to be overexpressed in Wnt-1-transformed cells. Remarkably, the transcription levels of the two homologous human genes NR4A1 and HERPUD1 are neither activated in cells with activated beta-catenin/TCF-mediated transcription nor can be induced by beta-catenin transfection. These results indicate different regulation mechanisms of the two genes in murine and human cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-1000501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-10087922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-10197631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-10201372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-10228155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-10349653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-10362259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-10555149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-10656974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-10708769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-10816074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-10947977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-11057903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-11134343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-11459829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-11713204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-11809808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-11809809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-213889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-2626032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-3186734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-6297757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-6546207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-7214343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-7584028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-7585508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-7705655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-8392847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-8605626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-8756721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-8757136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-8842743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-8994831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-9065401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-9065402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-9419423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-9425102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-9566868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-9601103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-9723002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-9727977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-9843955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12153396-9990071
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/WNT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
367
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
723-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12153396-Humans,
pubmed-meshheading:12153396-Animals,
pubmed-meshheading:12153396-Mice,
pubmed-meshheading:12153396-Transcription, Genetic,
pubmed-meshheading:12153396-Immunohistochemistry,
pubmed-meshheading:12153396-Signal Transduction,
pubmed-meshheading:12153396-Zebrafish Proteins,
pubmed-meshheading:12153396-Transfection,
pubmed-meshheading:12153396-Cytoskeletal Proteins,
pubmed-meshheading:12153396-Blotting, Northern
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