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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2002-8-1
pubmed:abstractText
Susceptibility to lung cancer may in part be attributable to inter-individual variability in metabolic activation or detoxification of tobacco carcinogens. The glutathione S-transferase M1 (GSTM1) genetic polymorphism has been extensively studied in this context; two recent meta-analyses of case-control studies suggested an association between GSTM1 deletion and lung cancer. At least 15 studies have been published after these overviews. We undertook a new meta-analysis to summarize the results of 43 published case-control studies including >18 000 individuals. A slight excess of risk of lung cancer for individuals with the GSTM1 null genotype was found (odds ratio (OR) = 1.17, 95% confidence interval (CI) 1.07-1.27). No evidence of publication bias was found (P = 0.4), however, it is not easy to estimate the extent of such bias and we cannot rule out some degree of publication bias in our results. A pooled analysis of the original data of about 9500 subjects involved in 21 case-control studies from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC) data set was performed to assess the role of GSTM1 genotype as a modifier of the effect of smoking on lung cancer risk with adequate power. Analyses revealed no evidence of increased risk of lung cancer among carriers of the GSTM1 null genotype (age-, gender- and center-adjusted OR = 1.08, 95% CI 0.98-1.18) and no evidence of interaction between GSTM1 genotype and either smoking status or cumulative tobacco consumption.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0143-3334
pubmed:author
pubmed-author:AlexandrieAnna-KarinAK, pubmed-author:BenhamouSimoneS, pubmed-author:BoffettaPaoloP, pubmed-author:BouchardyChristineC, pubmed-author:BrennanPaulP, pubmed-author:BrockmöllerJurgenJ, pubmed-author:ButkiewiczDorotaD, pubmed-author:ClapperMargie LML, pubmed-author:DalyAnnA, pubmed-author:DolzanVitaV, pubmed-author:FordJeanJ, pubmed-author:GaspariLauraL, pubmed-author:HaugenAageA, pubmed-author:HirvonenAriA, pubmed-author:Husgafvel-PursiainenKirstiK, pubmed-author:Ingelman-SundbergMagnusM, pubmed-author:KalinaIvanI, pubmed-author:KiharaMasahiroM, pubmed-author:KremersPierreP, pubmed-author:Le MarchandLoïcL, pubmed-author:LeeWon JinWJ, pubmed-author:LondonStephanie JSJ, pubmed-author:Nazar-StewartValleV, pubmed-author:Onon-KiharaMasakoM, pubmed-author:RannugAgnetaA, pubmed-author:RomkesMarjorieM, pubmed-author:RybergDavidD, pubmed-author:SeidegardJanericJ, pubmed-author:ShieldsPeterP, pubmed-author:StückerIsabelleI, pubmed-author:StrangeRichard CRC, pubmed-author:TaioliEmanuelaE, pubmed-author:To-FiguerasJordiJ
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1343-50
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk.
pubmed:affiliation
INSERM U521, EMI 00-06, Evry, France. benhamou@evry.inserm.fr
pubmed:publicationType
Journal Article