|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2002-8-1
|
|
pubmed:abstractText |
Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0968-0896
|
|
pubmed:author |
pubmed-author:AppendinoGiovanniG,
pubmed-author:CikMiroslavM,
pubmed-author:De KimpeNorbertN,
pubmed-author:HeWeidongW,
pubmed-author:LesageAnneA,
pubmed-author:LeysenJosée EJE,
pubmed-author:MathengeSimon GSG,
pubmed-author:MudidaFrancis PFP,
pubmed-author:Van DunJackyJ,
pubmed-author:Van PuyveldeLucL,
pubmed-author:Van der LindinIlseI,
pubmed-author:WoutersWalterW
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3245-55
|
|
pubmed:dateRevised |
2004-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:12150870-Animals,
pubmed-meshheading:12150870-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:12150870-Cell Survival,
pubmed-meshheading:12150870-Chick Embryo,
pubmed-meshheading:12150870-Diterpenes,
pubmed-meshheading:12150870-Ganglia, Spinal,
pubmed-meshheading:12150870-Humans,
pubmed-meshheading:12150870-Leukemia,
pubmed-meshheading:12150870-Models, Molecular,
pubmed-meshheading:12150870-Molecular Structure,
pubmed-meshheading:12150870-Nerve Growth Factors,
pubmed-meshheading:12150870-Neurons,
pubmed-meshheading:12150870-Terpenes,
pubmed-meshheading:12150870-Thymelaeaceae,
pubmed-meshheading:12150870-Triterpenes,
pubmed-meshheading:12150870-Tumor Cells, Cultured
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii.
|
|
pubmed:affiliation |
Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, Ghent, Belgium.
|
|
pubmed:publicationType |
Journal Article
|
