|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2002-7-30
|
|
pubmed:abstractText |
In this study, we characterized the self-renewal capability, multi-lineage differentiation capacity, and clonogenic efficiency of human dental pulp stem cells (DPSCs). DPSCs were capable of forming ectopic dentin and associated pulp tissue in vivo. Stromal-like cells were reestablished in culture from primary DPSC transplants and re-transplanted into immunocompromised mice to generate a dentin-pulp-like tissue, demonstrating their self-renewal capability. DPSCs were also found to be capable of differentiating into adipocytes and neural-like cells. The odontogenic potential of 12 individual single-colony-derived DPSC strains was determined. Two-thirds of the single-colony-derived DPSC strains generated abundant ectopic dentin in vivo, while only a limited amount of dentin was detected in the remaining one-third. These results indicate that single-colony-derived DPSC strains differ from each other with respect to their rate of odontogenesis. Taken together, these results demonstrate that DPSCs possess stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
D
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0022-0345
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
81
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
531-5
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12147742-Acid Phosphatase,
pubmed-meshheading:12147742-Adipocytes,
pubmed-meshheading:12147742-Adult,
pubmed-meshheading:12147742-Animals,
pubmed-meshheading:12147742-Bone Marrow Transplantation,
pubmed-meshheading:12147742-Cell Culture Techniques,
pubmed-meshheading:12147742-Cell Differentiation,
pubmed-meshheading:12147742-Cell Division,
pubmed-meshheading:12147742-Cell Lineage,
pubmed-meshheading:12147742-Clone Cells,
pubmed-meshheading:12147742-Collagen,
pubmed-meshheading:12147742-Dental Pulp,
pubmed-meshheading:12147742-Dentin,
pubmed-meshheading:12147742-Dentinogenesis,
pubmed-meshheading:12147742-Extracellular Matrix Proteins,
pubmed-meshheading:12147742-Flow Cytometry,
pubmed-meshheading:12147742-Humans,
pubmed-meshheading:12147742-Immunocompromised Host,
pubmed-meshheading:12147742-Isoenzymes,
pubmed-meshheading:12147742-Mice,
pubmed-meshheading:12147742-Mice, Inbred Strains,
pubmed-meshheading:12147742-Microscopy, Electron, Scanning,
pubmed-meshheading:12147742-Neurons,
pubmed-meshheading:12147742-Odontoblasts,
pubmed-meshheading:12147742-Odontogenesis,
pubmed-meshheading:12147742-Phosphoproteins,
pubmed-meshheading:12147742-Protein Precursors,
pubmed-meshheading:12147742-Regeneration,
pubmed-meshheading:12147742-Sialoglycoproteins,
pubmed-meshheading:12147742-Skin,
pubmed-meshheading:12147742-Stem Cell Transplantation,
pubmed-meshheading:12147742-Stem Cells,
pubmed-meshheading:12147742-Stromal Cells
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Stem cell properties of human dental pulp stem cells.
|
|
pubmed:affiliation |
Craniofacial and Skeletal Diseases Branch, Building 30, Room 228, NIDCR, NIH, Bethesda, MD 20892, USA
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
