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rdf:type |
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lifeskim:mentions |
umls-concept:C0004359,
umls-concept:C0017262,
umls-concept:C0018270,
umls-concept:C0023688,
umls-concept:C0030956,
umls-concept:C0039194,
umls-concept:C0205349,
umls-concept:C1171362,
umls-concept:C1327616,
umls-concept:C1334114,
umls-concept:C1510411,
umls-concept:C1515670,
umls-concept:C1527148
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pubmed:issue |
8
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pubmed:dateCreated |
2002-7-30
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pubmed:abstractText |
This study demonstrates that CD4(+) T cells specific for an altered self-antigen differentiate to T cells secreting transforming growth factor (TGF)-beta1. In this study, we utilized mice expressing an altered peptide ligand containing a single amino acid substitution of moth cytochrome c 88-103 peptide. In these mice, antigen-specific T cells escaping thymic negative selection differentiated into T cells with an effector/memory phenotype, CD44(high), CD45RB(low), CD62L(-) and CD25(intermediate). The expression of CD25 and high levels of CD44 was initiated in the thymus during the development from CD4(+)CD8(+) to CD4(+); a large proportion of maturing CD4(+) thymocytes expressed both CD25 and high levels of CD44. Upon antigen stimulation, CD4(+) T cells derived from these mice did not proliferate or secrete IL-2, but secreted TGF-beta1. Neutralizing antibodies to TGF-beta1 reversed the impaired proliferative responses to the antigen, suggesting that TGF-beta1 secreted from these T cells negatively regulates T cell responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD44,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome c Group,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0953-8178
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
857-65
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12147622-Amino Acid Sequence,
pubmed-meshheading:12147622-Amino Acid Substitution,
pubmed-meshheading:12147622-Animals,
pubmed-meshheading:12147622-Antigens, CD44,
pubmed-meshheading:12147622-Autoantigens,
pubmed-meshheading:12147622-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12147622-Cell Differentiation,
pubmed-meshheading:12147622-Clonal Anergy,
pubmed-meshheading:12147622-Cytochrome c Group,
pubmed-meshheading:12147622-Immunologic Memory,
pubmed-meshheading:12147622-Ligands,
pubmed-meshheading:12147622-Lymphocyte Activation,
pubmed-meshheading:12147622-Mice,
pubmed-meshheading:12147622-Mice, Inbred C57BL,
pubmed-meshheading:12147622-Mice, Transgenic,
pubmed-meshheading:12147622-Molecular Sequence Data,
pubmed-meshheading:12147622-Moths,
pubmed-meshheading:12147622-Peptides,
pubmed-meshheading:12147622-Phenotype,
pubmed-meshheading:12147622-Receptors, Interleukin-2,
pubmed-meshheading:12147622-Transforming Growth Factor beta,
pubmed-meshheading:12147622-Transforming Growth Factor beta1
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pubmed:year |
2002
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pubmed:articleTitle |
Development of CD25(+) T cells secreting transforming growth factor-beta1 by altered peptide ligands expressed as self-antigens.
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pubmed:affiliation |
Research Institute for Biological Sciences, Science University of Tokyo, 2669 Yamazaki, Noda City, Chiba 278-0022, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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