Linked Life Data

12145847

Source:http://linkedlifedata.com/resource/pubmed/id/12145847

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-7-30
pubmed:abstractText
Pre-eclampsia is a major complication of human pregnancy. Its trigger is from placental origin and may involve an abnormal placentation characterized by a defect of trophoblast invasion and an absence of remodelling of the maternal spiral arteries. In this study, we have characterized and developed a model of culture of extravillous trophoblast cells involved in human implantation. We showed that these cells expressed high levels of PPAR gamma by immunocytochemistry and real-time quantitative PCR. We showed that different natural ligands potentially present at the feto-maternal interface, such as oxidised low density lipoproteins, inhibited in vitro in a concentration dependent manner extravillous cytotrophoblast invasion. These results point to a key role of PPAR gamma in the pathology of pre-eclampsia.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-4079
pubmed:author
pubmed:issnType
Print
pubmed:volume
186
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-18; discussion 418-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
[Pathogenesis of pre-eclampsia: role of gamma PPAR in trophoblast invasion].
pubmed:affiliation
Institut National de la Santé et de la Recherche Médicale, U427, Université René Descartes, 4 avenue de l'Observatoire, 75006 Paris, France.
pubmed:publicationType
Journal Article, English Abstract