Linked Life Data

12144948

Source:http://linkedlifedata.com/resource/pubmed/id/12144948

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2002-7-29
pubmed:abstractText
Orexin-A and orexin-B are neuropeptides implicated in the maintenance of energy homeostasis. In the present study, we examined the effects of orexins on blood glucose levels in response to fasting in normal and streptozotocin-induced diabetic mice. After the injection of orexin-A and orexin-B (0.01-1 nmol/kg, i.v.), the blood glucose levels in both normal mice and diabetic mice in the fasting state decreased. In contrast, neither orexin-A nor orexin-B affected the glucose levels in the animals allowed free access to food. Intracerebroventricular administration of orexin-A and orexin-B was associated with glucose-lowering effects in fasting diabetic mice. The serum insulin level did not significantly change following the administration of orexin-A or orexin-B, in either the normal or the diabetic mice in the fasting state. These results demonstrate that orexins lower the blood glucose levels exclusively in the fasting state. The orexins may stimulate some neural and hormonal network and thereby promote blood glucose utilization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-2999
pubmed:author
pubmed:copyrightInfo
Copyright 2002 Elsevier Science B.V.
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
448
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Reduction of blood glucose level by orexins in fasting normal and streptozotocin-diabetic mice.
pubmed:affiliation
Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't