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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-7-29
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pubmed:abstractText |
The HPV16/18 code for an oncoprotein-E6, which binds to p53 tumor suppressor protein and degrades the protein via ubiquitination. A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo. Hence, in the current study we investigated the prevalence of HPV16/18 in cervical lesions and the distribution of p53 genotypes in cervical cancers and normal healthy women.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0090-8258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12144822-Arginine,
pubmed-meshheading:12144822-Carcinoma, Squamous Cell,
pubmed-meshheading:12144822-Cervix Uteri,
pubmed-meshheading:12144822-DNA, Viral,
pubmed-meshheading:12144822-Disease Progression,
pubmed-meshheading:12144822-European Continental Ancestry Group,
pubmed-meshheading:12144822-Female,
pubmed-meshheading:12144822-Genotype,
pubmed-meshheading:12144822-Humans,
pubmed-meshheading:12144822-India,
pubmed-meshheading:12144822-Papillomaviridae,
pubmed-meshheading:12144822-Papillomavirus Infections,
pubmed-meshheading:12144822-Polymerase Chain Reaction,
pubmed-meshheading:12144822-Polymorphism, Genetic,
pubmed-meshheading:12144822-Prevalence,
pubmed-meshheading:12144822-Proline,
pubmed-meshheading:12144822-Tumor Suppressor Protein p53,
pubmed-meshheading:12144822-Tumor Virus Infections,
pubmed-meshheading:12144822-Uterine Cervical Neoplasms
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pubmed:year |
2002
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pubmed:articleTitle |
HPV16/18 prevalence in cervical lesions/cancers and p53 genotypes in cervical cancer patients from India.
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pubmed:affiliation |
Laboratory of Cancer Genes, Cancer Research Institute, Tata Memorial Centre, Parel, Mumbai, 400 012, India. dsaranath@netscape.net
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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