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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-7-26
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pubmed:abstractText |
Cloned T9 glioma cells (T9-C2) expressing the membrane form of macrophage colony stimulating factor (mM-CSF) inoculated subcutaneously into rats do not grow and glioma-specific immunity is stimulated. Immunotherapy experiments showed that intracranial T9 tumors present for one to four days could be successfully eradicated by peripheral vaccination with T9-C2 cells. CD4+ and CD8+ T splenocytes from immunized rats, when restimulated in vitro with T9 cells, produced interleukin-2 and -4. Protective immunity against intracranial T9 gliomas could only be adoptively transferred into naive rats by the CD4+ splenocytes obtained from T9-C2 immunized rats. Rats immunized by the T9-C2 tumor cells also resisted two different syngeneic gliomas (RT2 and F98) but allowed a syngeneic NUTU-19 ovarian cancer to grow. Such cross-protective immunity against unrelated gliomas suggests that mM-CSF transfected tumor cells have immunotherapeutic potential for use as an allogeneic tumor vaccine.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-8749
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pubmed:author |
pubmed-author:Al AtarUsamaU,
pubmed-author:ArpajirakulNearyN,
pubmed-author:ChenYijunY,
pubmed-author:DanQinghongQ,
pubmed-author:DazaJose LJL,
pubmed-author:DelgadoChristinaC,
pubmed-author:DouglassThomasT,
pubmed-author:JadusMartin RMR,
pubmed-author:JeffesEdward W BEW,
pubmed-author:KimRonald CRC,
pubmed-author:SanchezRamonR,
pubmed-author:Terry WepsicHH,
pubmed-author:WilliamsChristopherC,
pubmed-author:XuQingchengQ
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pubmed:issnType |
Print
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pubmed:volume |
215
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-11
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12142031-Adoptive Transfer,
pubmed-meshheading:12142031-Animals,
pubmed-meshheading:12142031-Brain Neoplasms,
pubmed-meshheading:12142031-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12142031-Cells, Cultured,
pubmed-meshheading:12142031-Clone Cells,
pubmed-meshheading:12142031-Female,
pubmed-meshheading:12142031-Glioma,
pubmed-meshheading:12142031-Interleukin-2,
pubmed-meshheading:12142031-Interleukin-4,
pubmed-meshheading:12142031-Kinetics,
pubmed-meshheading:12142031-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:12142031-Membrane Proteins,
pubmed-meshheading:12142031-Neoplasm Transplantation,
pubmed-meshheading:12142031-RNA, Messenger,
pubmed-meshheading:12142031-Rats,
pubmed-meshheading:12142031-Rats, Inbred F344,
pubmed-meshheading:12142031-Survival Analysis,
pubmed-meshheading:12142031-Transfection,
pubmed-meshheading:12142031-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
T9 glioma cells expressing membrane-macrophage colony stimulating factor produce CD4+ T cell-associated protective immunity against T9 intracranial gliomas and systemic immunity against different syngeneic gliomas.
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pubmed:affiliation |
Diagnostic and Molecular Health Care Group, Box 113 Veterans Affairs Medical Center, 5901 E. 7th Street, Long Beach, CA 90822, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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