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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-7-26
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pubmed:abstractText |
The neurexins are a large family of neuronal cell-surface proteins believed to be involved in intercellular signalling and the formation of intercellular junctions. To begin to assess the role of these proteins in the olfactory bulb, we describe here the expression patterns of their transmembrane and secreted ligands, the neuroligins and neurexophilins, during both embryonic and postnatal development. In situ hybridisation showed that neuroligin 1 and 2 were expressed by second order mitral cells during early postnatal development but not in adults. The secreted ligand for alpha-neurexin, neurexophilin 1, was also expressed in the postnatal olfactory bulb. Neurexophilin 1 was detected in only periglomerular cells during the early postnatal period of glomerular formation but later was also expressed in mitral cells. These results suggest that neurexin-ligand interactions may be important for development and/or maturation of synaptic connections in the primary olfactory pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules, Neuronal,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotide Probes,
http://linkedlifedata.com/resource/pubmed/chemical/neurexin Ibeta,
http://linkedlifedata.com/resource/pubmed/chemical/neurexophilin,
http://linkedlifedata.com/resource/pubmed/chemical/neuroligin 1,
http://linkedlifedata.com/resource/pubmed/chemical/neuroligin 2
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pubmed:status |
MEDLINE
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pubmed:issn |
0214-6282
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
649-52
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12141453-Animals,
pubmed-meshheading:12141453-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:12141453-DNA Primers,
pubmed-meshheading:12141453-Gene Expression Regulation, Developmental,
pubmed-meshheading:12141453-Glycoproteins,
pubmed-meshheading:12141453-In Situ Hybridization,
pubmed-meshheading:12141453-Ligands,
pubmed-meshheading:12141453-Membrane Proteins,
pubmed-meshheading:12141453-Mice,
pubmed-meshheading:12141453-Mice, Inbred C57BL,
pubmed-meshheading:12141453-Nerve Tissue Proteins,
pubmed-meshheading:12141453-Neuropeptides,
pubmed-meshheading:12141453-Olfactory Bulb,
pubmed-meshheading:12141453-Oligonucleotide Probes,
pubmed-meshheading:12141453-Rats,
pubmed-meshheading:12141453-Rats, Sprague-Dawley,
pubmed-meshheading:12141453-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12141453-Time Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb.
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pubmed:affiliation |
Department of Anatomy and Developmental Biology, University of Queensland, Brisbane, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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