Linked Life Data

12141445

Source:http://linkedlifedata.com/resource/pubmed/id/12141445

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-7-26
pubmed:abstractText
The neurotrophins are a family of secreted proteins with critical roles in regulation of many aspects of neural development, survival and maintenance. Their actions on neural tissue are thought to be mediated by interaction with high affinity (trk family members) or low affinity (p75NTR) cell surface receptors. In general, neurotrophins are considered to be supplied in limiting quantity by cells of a target tissue or synaptic partner. To date, alpha motoneurons have been shown surprisingly indifferent to loss of neurotrophic factors. Direct evidence for supply of a critical motoneuron factor(s) by skeletal muscle and a specific uptake mechanism in vivo remains elusive. We wished to directly establish whether targets in the periphery might be potential sources of neurotrophic support for motoneurons by examining whether neurotrophin receptors are present on motoneuron nerve terminals. We have used immunofluorescence techniques with a panel of antibodies against known neurotrophin receptors (trk A, trk B, trk C, p75NTR) to map the locations of these receptors in the developing neuromuscular system of mice from our neurotrophin-3 (NT-3) knockout colony. To our surprise, we failed to locate immunoreactivity for any of these receptors in association with motor nerve endplates or terminal intramuscular axon branches, although they were found in association with a population of unidentified cells. We believe this result indicates that the neurotrophic relationship between alpha motoneurons and their target cells is not a simple one of neurotrophin supply by skeletal muscle cells and its uptake at the neuromuscular junction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0214-6282
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
569-75
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Distribution of neurotrophin receptors in the mouse neuromuscular system.
pubmed:affiliation
Department of Physiology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand. phil.sheard@stonebow.otago.ac.nz
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't